摘要
目的探讨米索前列醇联合垂体后叶素治疗产后出血产妇的疗效及对其凝血因子水平的影响,为临床治疗提供参考依据。方法选取2017年6月-2018年5月在杭州师范大学附属医院妇产科收治的产后出血46例产妇作为研究对象。按照随机数字表法将所有产妇分为观察组与对照组。对照组产妇用缩宫素治疗,观察组在对照组治疗基础上采用米索前列醇联合垂体后叶素治疗。对比两组产妇胎儿娩出后2 h、24 h内的子宫出血量,治疗疗效,凝血因子水平。对治疗后两组产妇的不良反应情况进行记录与分析。结果治疗前,两组产妇的胎儿娩出后2 h、24 h内的子宫出血量差异无统计学意义(均P<0. 05)。治疗后,两组产妇的胎儿娩出后2 h、24 h内的子宫出血量明显降低,观察组产妇的胎儿娩出后2 h、24 h内的子宫出血量明显低于对照组产妇,差异有统计学意义(均P<0. 05)。观察组产妇的治疗总有效率(95. 83%)明显高于对照组产妇的治疗总有效率(72. 73%),差异有统计学意义(P<0. 05)。治疗前两组产妇的血小板计数(PLT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)以及纤维蛋白原(FIB)水平差异无统计学意义(均P>0. 05);治疗后观察组与对照组产妇的PLT、APTT、PT水平均明显低于治疗前,FIB水平明显高于治疗前,差异有统计学意义(均P<0. 05)。观察组产妇的PLT、APTT、PT水平明显低于对照组,FIB水平明显高于对照组,差异有统计学意义(均P<0. 05)。观察组产妇的不良反应发生率(8. 33%)与对照组产妇的不良反应发生率(9. 09%)相比,差异无统计学意义(P>0. 05)。结论米索前列醇联合垂体后叶素治疗产后出血产妇疗效显著,能够有效改善凝血因子的水平,有助于减少产后出血量。
Objective To explore the curative effect of misoprostol combined with pituitrin in treatment of postpartum hemorrhage and the impact on coagulation factors,provide a reference basis for clinical treatment of postpartum hemorrhage. Methods From June 2017 to May 2018,46 women with postpartum hemorrhage were selected from Department of Gynecology and Obstetrics,Affiliated Hospital of Hangzhou Normal University,then they were divided into observation group and control group according to random number table. The women in control group were treated by oxytocin,and the women in observation group were treated by oxytocin,misoprostol combined with pituitrin.The volumes of uterine bleeding within 2 and 24 hours after delivery,therapeutic effects,and the levels of coagulation factors were compared between the two groups. The adverse reactions after treatment in the two groups were recorded and analyzed. Results Before treatment,there was no statistically significant difference in the volumes of uterine bleeding within 2 and 24 hours after delivery between the two groups( P<0. 05). After treatment,the volumes of uterine bleeding within 2 and 24 hours after delivery in the two groups decreased significantly,the volumes of uterine bleeding within 2 and 24 hours after delivery in observation group were statistically significantly lower than those in control group( P<0. 05). The total effective rate in observation group( 95. 83%) was statistically significantly higher than that in control group( 72. 73%)( P<0. 05). Before treatment,there was no statistically significant difference in platelet count( PLT),activated partial thromboplastin time( APTT),prothrombin time( PT),and fibrinogen( FIB) levels between the two groups( P> 0. 05);after treatment,PLT,APTT,and PT levels in the two groups were statistically significantly lower than those before treatment,while the levels of FIB in the two groups were significantly higher than those before treatment( P<0. 05). The levels of PLT,APTT,and PT in observation group were statistically significantly lower than those in control group,while the level of FIB in observation group was statistically significantly higher than that in control group( P<0. 05). There was no statistically significant difference in the incidence rate of adverse reactions between observation group( 8. 33%) and control group( 9. 00%)( P>0. 05). Conclusion The curative effect of misoprostol combined with pituitrin in treatment of postpartum hemorrhage is significant,the therapy can effectively improve the levels of coagulation factors and reduce the volume of postpartum hemorrhage.
作者
徐丽燕
陈香君
倪娟
CHEN Li-Yan;CHEN Xiang-Jun;NI Juan(Department of Gynecology and Obstetrics,Affiliated Hospital of Hangzhou Normal University,the Second Peopled Hospital of Hangzhou,Hangzhou,Zhejiang 310015,China)
出处
《中国妇幼保健》
CAS
2019年第24期5587-5590,共4页
Maternal and Child Health Care of China
关键词
米索前列醇
垂体后叶素
产后出血
凝血因子
止血
缩宫素
Misoprostol
Pituitrin
Postpartum hemorrhage
Coagulation factor
Hemostasis
Oxytocin
