摘要
中药引起的不良反应中类过敏反应发生率逐年增高,对人类健康造成了严重的威胁。由于国内外对类过敏反应发生的机制尚不完全清楚,评价方法尚不成熟,导致药物类过敏反应的预测与评价存在不同程度的局限性。为了更好地了解类过敏反应,解决中药致敏成分的研究与中药注射剂的安全性评价问题,总结归纳了目前有关药物诱导的类过敏反应发生机制及临床前评价模型等内容,通过对比分析,为后期深入研究提供依据和方法学指导。
The incidence of pseudo-allergy is the highest among the adverse drug reactions induced by Traditional Chinese Medicine(TCM), which threatens the public health seriously. The lack of research on mechanisms and evaluation models of pseudo-allergy results in different degrees of limitation on prediction and assessment on safety of drugs. In order to better understand the kind of allergic reaction, solve the allergic components and improve the safety of TCM, we summarize the mechanisms and evaluation models in vitro and in vivo of drug-induced pseudo-allergy for further study.
作者
王璐
龚光明
苏华
WANG Lu;GONG Guangming;SU Hua(Department of Preparation,Jinling Hospital,Nanjing 210002,China)
出处
《药物评价研究》
CAS
2019年第12期2471-2477,共7页
Drug Evaluation Research
基金
军队医疗机构制剂标准提高科研专项(14ZJZ08)
关键词
中药
类过敏反应
发生机制
评价模型
traditional Chinese medicine
pseudo-allergy
mechanism
evaluation model
