摘要
目的基于文献探索中医治疗哮喘的辨证用药规律。方法检索中国临床文献数据库,以及中国生物医学文献服务系统(SinoMed)、中国期刊全文数据库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)1949年1月1日-2017年12月31日有关中医治疗哮喘的临床研究文献,通过人机结合的方式,抽取疾病、证型、药物组成等关键信息,构建数据库。使用中医药数据挖掘系统(http://tcmminer.cintcm.com:8023/tcm/index.jsp)计算证型-中药的共现矩阵及针对不同证型的中药频繁项集,分析中医辨证治疗哮喘的组方规律,并针对5个高频证型提出新药处方。结果共纳入文献234篇,包含处方1337首、证型124个、中药290味。高频证型前5位为热哮证、寒哮证、痰热壅盛证、肺脾气虚证、肾阳虚证。最常用的中药前5位为麻黄、苦杏仁、甘草、地龙、五味子。分析5个高频证型的中药频繁项集,演化得到5个新药处方,热哮证处方为地龙、黄芩、苦杏仁、麻黄、桑白皮、甘草、紫苏子;寒哮证处方为紫苏子、麻黄、地龙、细辛、半夏、苦杏仁、五味子;痰热壅肺证处方为苦杏仁、麻黄、地龙、款冬花、桑白皮、甘草;肺脾气虚证处方为白术、黄芪、山萸肉、茯苓、党参、桑白皮、五味子;肾阳虚证处方为五味子、补骨脂、茯苓、紫苏子、黄芩、生地黄。结论不同的证型使用的高频中药明显不同,提示区分证型对中医处方进行挖掘分析更符合中医辨证论治的思想精髓。
Objective To explore the rules of TCM treatment of Asthma on different syndromes.Methods We searched the modern clinical literature of asthma treated by TCM form Chinese Clinical Literature Database,SinoMed,CNKI,Wanfang Database and CQVIP from 1949-2017,collected key information such as diseases,syndromes,and drug composition by human-computer integration and constructed a database.We calculated the co-occurrence matrix of syndrome-herb and the frequent item sets of herb for different syndromes using TCM Miner(http://tcmminer.cintcm.com:8023/tcm/index.jsp).The prescription and treatment of asthma with different syndrome were analyzed,and a new medicine prescription was proposed for common five kinds of common syndromes.Results There were 234 articles containing 124 syllables,1337 prescriptions and 290 herbs.For different syndromes,the high-frequency medicine was obviously different,which reflected the important ideas of TCM syndrome differentiation.According to five common syndromes including fever syndrome,cold syndrome,lung-spleen qi deficiency syndrome and kidney-yang deficiency syndrome,five new drug prescriptions have evolved.Conclusions Analysis of TCM prescriptions based on differentiating syndromes can explore the essence of TCM and provided ideas and data support for researchers.
作者
唐农
李宗友
亢力
杨硕
雷蕾
Tang Nong;Li Zongyou;Kang Li;Yang Shuo;Lei Lei(Guangxi University of Chinese Medicine,Nanning 530299,China;Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Traditional Chinese Medicine Information Technology Research Office,Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Scientific Research and Education Department,Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《国际中医中药杂志》
2019年第12期1370-1374,共5页
International Journal of Traditional Chinese Medicine
基金
广西高校人文社会科学重点研究基地基金(2017)。
关键词
哮喘
组方规律
频繁项集
共现矩阵
新药处方
数据挖掘
Asthma
Formula composing rules
Frequent item sets
Co-occurrence matrix
Prescription for new drugs
Data mining
