摘要
Dear Editor,Interleukin-25(IL-25,also called IL-17E)is an important IL-17 family member that helps initialize and regulate type 2 immunity,exerting an important influence on the pathogenesis of asthma(Corrigan et al.,2011;Barlow et al.,2012).Furthermore,it plays a vital role in initiating type 2 innate lymphoid cell activation and maintenance(Tong and Li,2018)and inducing Th2-type cytokine-mediated allergic airway eosinophilia(Morita et al.,2015).IL-25 expression increases in patients with asthma in different types of lung cells,including lung structural cells(such as endothelium and airway epithelium),eosinophils,T-cells,and mast cells.Following allergen exposure,cells in the bronchial submucosa increase and secrete or respond to IL-25(Corrigan et al.,2011).Plasma IL-25 levels increase in patients with asthma and correlate with lung function(Cheng et al.,2014).The association between IL-25 cells and pulmonary function indicates that IL-25 could be used to monitor asthma severity.In some mouse models,epithelial IL-25 cytokines are closely related with a range of airway inflammation modalities,including type 2 cytokine production,airway eosinophil inflammation,mucinous epithelial metaplasia,and airway hyperresponsiveness(AHR)(Suzukawa et al.,2012).
基金
supported by the Health and Family Planning Commission of Jinan Municipality (2018-1-32)
Shandong Health and Family Planning Commission (2018WS489, 2018WS490)
Jinan Science Technology Bureau (20180519)
