摘要
目的:探讨益生菌在小儿咳嗽变异性哮喘(CVA)中的治疗作用。方法:选取2016年7月-2017年1月笔者所在医院临床确诊CVA患儿80例,将其随机分为两组,每组40例。对照组仅予以布地奈德雾化治疗,试验组在对照组基础上予以口服益生菌(双歧杆菌乳杆菌三联活菌片)。比较两组患儿治疗前后肺活量(FVC)、第1秒末用力呼气量(FEV1)及呼气峰流速(PEF),以及治疗后咳嗽复发次数,咳嗽持续时间、治疗效果。结果:试验组治疗总有效率为95%,对照组治疗总有效率90%,组间比较差异无统计学意义(P>0.05)。治疗前两组FVC、FEV1、PEF等肺通气功能比较差异均无统计学意义(P>0.05);治疗后两组FVC、FEV1、PEF均较治疗前显著改善(P<0.05),但两组治疗后比较差异均无统计学意义(P>0.05)。治疗后观察组咳嗽发作次数少于对照组,咳嗽持续时间短于对照组,差异有统计学意义(P<0.05)。治疗过程中,两组均无不良反应发生。结论:益生菌联合布地奈德治疗小儿咳嗽变异性哮喘可明显减少复发次数,且无明显不良反应,适合临床使用。
Objective:To investigate the therapeutic effect of probiotics on children with cough variant asthma(CVA).Method:A total of 80 children with CVA diagnosed in our hospital from July 2016 to January 2017 were selected and randomly divided into two groups,40 cases in each group.The control group was treated with Budesonide inhalation only.The experimental group was treated with oral probiotics(Bifidobacterium Lactobacillus Trifecta Live Bacteria Tablet)on the basis of the control group.The vital capacity(FVC),forced expiratory volume at the end of the first second(FEV1)and peak expiratory flow(PEF)before and after treatment were compared between the two groups,as well as the number of cough recurrence and duration of cough and therapeutic effect.Result:The total effective rate of the experimental group was 95%,and 90%in the control group,the difference between the two groups was no significant difference(P>0.05).There were no significant differences in FVC,FEV1 and PEF between the two groups before treatment(P>0.05).After treatment,FVC,FEV1 and PEF in the two groups were significantly improved compared with that before treatment(P<0.05),but there was no significant difference between the two groups after treatment(P>0.05).After treatment,the number of cough recurrence in the observation group was less than that in the control group,and the duration of cough was shorter than that in the control group,the differences were statistically significant(P<0.05).During the treatment,no adverse reactions occurred in both groups.Conclusion:Probiotics combined with Budesonide in the treatment of cough variant asthma in children can significantly reduce the number of cough recurrence,and no obvious adverse reactions,suitable for clinical use.
作者
朱学龙
余国庆
张展
ZHU Xuelong;YU Guoqing;ZHANG Zhan(Nanjing Qixia District Women and Children Health Care Hospital,Nanjing 241002,China;不详)
出处
《中外医学研究》
2019年第36期150-152,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
益生菌
咳嗽变异性哮喘
儿童
疗效
Probiotics
Cough variant asthma
Children
Therapeutic effect
