摘要
目的:分析缬沙坦氢氯噻嗪片联合阿罗洛尔对顽固性高血压患者血生化指标及不良反应的影响。方法:遴选108例顽固性高血压患者,将其随机分为治疗组(n=54)和对照组(n=54)。治疗组应用缬沙坦氢氯噻嗪片联合阿罗洛尔治疗,对照组仅应用缬沙坦氢氯噻嗪片治疗。观察两组血压和生化指标的变化,记录不良反应发生情况。结果:治疗后,治疗组DBP(83.57±4.62)mm Hg,SBP(137.16±9.25)mm Hg,HR为(64.73±2.85)次/min,均优于对照组,差异有统计学意义(P<0.05)。两组治疗后血糖、血钾、肌酐水平与治疗前比较,差异均无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:缬沙坦氢氯噻嗪片联合阿罗洛尔治疗顽固性高血压的临床效果显著,值得推广应用。
Objective:To analyze the effects of Valsartan Hydrochlorothiazide Tablets combined with Arotinolol on blood biochemical indexes and adverse reactions for patients with refractory hypertension.Method:A total of 108 patients with refractory hypertension were selected and randomly divided into the treatment group(n=54)and the control group(n=54).The treatment group was treated with Valsartan Hydrochlorothiazide Tablets combined with Arotinolol,while the control group was treated with Valsartan Hydrochlorothiazide Tablets alone.The changes of blood pressure and biochemical indexes in the two groups were observed,and the occurrence of adverse reactions was recorded.Result:After treatment,DBP in the treatment group was(83.57±4.62)mm Hg,SBP was(137.16±9.25)mm Hg,and HR was(64.73±2.85)times/min,which were better than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in blood glucose,potassium and creatinine between the two groups after treatment and before treatment(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The clinical effect of Valsartan Hydrochlorothiazide Tablets combined with Arotinolol in the treatment of refractory hypertension is remarkable,which is worthy of promotion and application.
作者
徐进林
陈咏梅
刘桂秀
XU Jinlin;CHEN Yongmei;LIU Guixiu(Xiantao First People’s Hospital Affiliated to Changjiang University,Xiantao 433000,China)
出处
《中外医学研究》
2019年第36期40-42,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
缬沙坦
氢氯噻嗪
阿罗洛尔
顽固性高血压
Valsartan
Hydrochlorothiazide
Arotinolol
Refractory hypertension
