摘要
目的:分析丙戊酸钠与左乙拉西坦治疗小儿癫痫临床效果。方法:选取笔者所在医院小儿癫痫患儿92例(2017年6月-2018年7月),将其随机分为丙戊酸钠治疗的对照组(46例)与左乙拉西坦治疗的观察组(46例),观察两组患者治疗效果、认知功能、血钙磷水平、痫样放电好转率及不良反应发生率。结果:两组治疗总有效率、不良反应发生率比较,差异均无统计学意义(P>0.05)。观察组认知功能、血钙磷水平均优于对照组,痫样放电总好转率优于对照组,差异有统计学意义(P<0.05)。结论:给予小儿癫痫患儿丙戊酸钠与左乙拉西坦治疗,两种药物治疗效果相当,不良反应少,安全性高,相比于丙戊酸钠,左乙拉西坦能提高患者认知功能及痫样放电总好转率,降低血钙磷水平,值得借鉴。
Objective:To analyze the clinical effect of Valproate and Levetiracetam in the treatment of pediatric epilepsy.Method:A total of 92 children with pediatric epilepsy in our hospital(from June 2017 to July 2018)were randomly divided into the control group(46 cases)treated with Valproate and the observation group(46 cases)treated with Levetiracetam.The therapeutic effect,cognitive function,blood calcium and phosphorus level,epileptic discharge rate,and incidence of adverse reactions were observed.Result:There were no significant differences in the total effective rate and incidence of adverse reactions between the two groups(P>0.05).The cognitive function,blood calcium and phosphorus levels of the observation group were better than those of the control group,the total recovery rate of epileptic discharge was better than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Valproate and Levetiracetam for the treatment of pediatric epilepsy,two drugs treatment effect is similar,less adverse reactions,high safety.Compared with Valproate,Levetidine can improve patients’cognitive function and total recovery rate of epileptic discharge,and reduce blood calcium and phosphorus level,which is worthy of reference.
作者
张光林
ZHANG Guanglin(Sanming Second Hospital,Yong’an 366000,China)
出处
《中外医学研究》
2019年第36期9-11,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
三明市科技计划项目（项目编号：2017-S-3）
