摘要
目的:观察贝母瓜蒌合剂治疗儿童肺炎支原体肺炎(mycoplasmal pneumoniae pneumonia,MPP)的临床疗效。方法:将80例MPP患儿按照随机数字表法分为对照组和治疗组,每组各40例。对照组给予阿奇霉素序贯疗法,治疗组口服阿奇霉素及贝母瓜蒌合剂。比较两组患儿的临床疗效、中医证候疗效及治疗前后症状积分变化情况,检测两组患儿治疗前后外周血血清白细胞介素-6(interleukin-6,IL-6)及白细胞介素-10(interleukin-10,IL-10)水平。结果:临床疗效:对照组愈显率为75.00%,治疗组愈显率为77.50%,两组患儿愈显率比较,差异无统计学意义(P>0.05)。证候疗效:对照组愈显率为70.00%,治疗组愈显率为90.00%,两组患儿愈显率比较,差异有统计学意义(P<0.05)。两组患儿治疗后主要症状积分、次要症状积分低于本组治疗前,且治疗组治疗后咳嗽、痰壅、肺部体征、精神、食欲及大便等积分低于对照组,差异具有统计学意义(P<0.05)。两组患儿治疗后IL-6、IL-10水平低于本组治疗前,且治疗组低于对照组治疗后,差异具有统计学意义(P<0.05)。结论:贝母瓜蒌合剂治疗儿童MPP,可改善患儿的临床症状,同时对细胞免疫具有一定的调节作用。
Objective:To observe the clinical curative effect of Mixture of Fritillaria and Trichosanthes on mycoplasma pneumoniae pneumonia(MPP) in children.Methods:According to the random number table method,80 children with MPP were divided into the control group and the treatment group,with 40 cases in each group.The control group was given Azithromycin sequential therapy,and the treatment group was given Azithromycin and Mixture of Fritillaria and Trichosanthes together.Then the clinical efficacy,TCM syndrome efficacy and symptom score before and after the treatment were compared between the two groups.The serum levels of I interleukin-6(L-6) and interleukin-10(IL-10) were measured before and after the treatment.Results:In terms of clinical efficacy:the remarkable cure rate of the control group was 75.00%,and that of the treatment group was 77.50%.There was no significant difference between the two groups(P>0.05).In terms of TCM syndrome clinical efficacy:the remarkable cure rate of the control group was 70.00%,and that of the treatment group was 90.00%.There was significant difference between the two groups(P<0.05).After the treatment,the scores of main symptoms and secondary symptoms in the two groups were lower than those of the same group before the treatment,and the above indexes in the treatment group were lower than those in the control group after the treatment,and all the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6 and IL-10 in the two groups were lower than those before the treatment,and all the differences between the two groups were statistically significant(P<0.05).Conclusion:Mixture of Fritillaria and Trichosanthes has a remarkable efficacy on children with MPP,can improve the clinical symptoms of children and regulate the cellular immunity to some extent.
作者
王颖
李建来
刘俊俊
WANG Ying;LI Jian-lai;LIU Jun-jun(Weifang Hospital of TCM,Weifang,Shandong,China,261041)
出处
《河南中医》
2019年第12期1858-1861,共4页
Henan Traditional Chinese Medicine
基金
潍坊市科技发展计划项目(2017YX048)
关键词
儿童肺炎支原体肺炎
贝母瓜蒌合剂
阿奇霉素
序贯疗法
mycoplasma pneumoniae pneumonia in children
Mixture of Fritillaria and Trichosanthes
Azithromycin
sequential therapy
