摘要
目的探讨肝硬化合并食管胃底静脉曲张破裂出血采用凝血酶与奥曲肽联合治疗的疗效。方法选取本院2016年4月至2018年2月收治的肝硬化合并食管胃底静脉曲张破裂出血患者106例,按单盲法分为对照组和试验组,各53例。对照组采用奥曲肽治疗,试验组采用凝血酶与奥曲肽联合治疗。连续治疗3 d后,比较2组临床疗效、输血量、止血时间、症状改善时间及不良反应发生情况。结果试验组总有效率(94%)较对照组(81%)高,差异具有统计学意义(P<0.05);试验组输血量(225±29)mL较对照组(397±30)mL少,止血时间(18±3)h、黑便改善时间(30±4)h、呕血改善时间(30±4)h较对照组[(23±4)、(54±5)h、(49±3)h]短,差异具有统计学意义(P<0.05);试验组不良反应总发生率(9%)与对照组(13%)相比,差异无统计学意义(P>0.05)。结论肝硬化合并食管胃底静脉曲张破裂出血采用凝血酶联合奥曲肽治疗效果确切,可缩短止血时间及症状改善时间,减少出血量,提升治疗效果,且不良反应少,安全性较高。
Objective To investigate the efficacy of thrombin combined with octreotide in treatment of liver cirrhosis and esophagogastric variceal bleeding(EGVB).Methods One hundred and six patients with liver cirrhosis and EGVB in the hospital from April 2016 to February 2018 were selected,and they were divided into control group and experimental group by single blind method,with 53 cases in each group.Control group took octreotide,while experimental group was treated with thrombin and octreotide,After treatment for 3d,the clinical efficacy,blood transfusion volume,hemostatic time,improvement time of symptoms,adverse reactions were compared between the two groups.Results The total effective rate of experimental group(94%)was higher than control group(81%)(P<0.05);The blood transfusion volume of experimental group[(225±29)mL]was less than control group[(397±30)mL],the hemostatic time,improvement time of melena,improvement time of hematemesis in experimental group[(18±3)h,(30±4)h,(30±4)h]were shorter than those of the control group[(23±4)h,(54±5)h,(49±3)h](P<0.05);There was no statistical difference in the total incidence of adverse reactions between experimental group(9%)and control group(13%)(P>0.05).Conclusion Thrombin combined with octreotide in treatment of liver cirrhosis and EGVB is effective.It can shorten hemostatic time and improvement time of symptoms,reduce bleeding volume,increase curative effects,have less adverse reactions and higher safety.
作者
乔新勋
Qiao Xinxun(Department of Internal Medicine,Zhengzhou Sixteen People′s Hospital,Henan 450000,China)
出处
《山西医药杂志》
CAS
2020年第1期22-24,共3页
Shanxi Medical Journal
关键词
肝硬化
食管和胃静脉曲张
凝血酶
奥曲肽
Liver cirrhosis
Esophageal and gastric varices
Thrombin
Octreotide
