摘要
目的探讨老年患者在放化疗期间口腔黏膜炎的发生率及其对生活质量的影响。方法选择2016年11月~2017年10月期间141名年龄在60岁以上接受放化疗的患者,完成为期14天的口腔黏膜炎每日问卷(OMDQ)的自我报告,并在基线、第7天和第14天完成口腔黏膜炎特异性生活质量量表(OMQoL)。采用线性回归模型评估症状对生活质量的影响。结果在141名患者中,有57名患者发生口腔黏膜炎,发生率为40.4%,其中,32例报告的OMDQ评分最高为2(轻度黏膜炎),25例报告的OMDQ评分最高为3~4(重度黏膜炎)。与无黏膜炎和轻度黏膜炎患者相比,重度黏膜炎患者出现严重症状和同时出现吞咽、喝水、进食、说话和睡眠困难症状的几率更高(P<0.001)。重度黏膜炎组的五种症状AUC评分(1.07)显著高于轻度黏膜炎组(0.66)和无黏膜炎组(0.03)(P<0.001)。重度黏膜炎组(75.50)和轻度黏膜炎组(79.87)的OMQoL症状、饮食、社会功能和吞咽AUC评分均显著低于无黏膜炎组(平均96.77)。吞咽困难和睡眠困难在OMQoL分量表得分(吞咽:-0.321^-0.767;睡眠:-0.406^-0.773)和心理困扰得分(分别为0.468和0.557)中具有最强的标准化系数。结论黏膜炎在接受放化疗的老年患者中非常常见,相关症状可能对患者的生活质量和心理产生很大影响。
Objective To investigate the incidence of oral mucositis and the impact on quality of life in elderly patients during radiotherapy and chemotherapy.Methods A total of 114 patients over 60 years old who received radiotherapy and chemotherapy were included.A 14-day oral mucositis daily questionnaire(OMDQ)self-report nd the oral mucositis specific quality of life scale(OMQoL)on the baseline,the 7th day and the 14th day were completed.A linear regression model was used to evaluate the effect of symptoms on quality of life.Results Fifty-seven of 141 patients had oral mucositis,with an incidence of 40.4%.Among the 57 patients with oral mucositis,32 cases had the highest OMDQ score of 2(mild mucositis),25 cases had the score of 3 to 4(severe mucositis).Compared with the patients without mucositis and with mild mucositis,patients with severe mucositis were more likely to have severe symptoms such as swallowing,drinking,eating,speaking and sleeping difficulties.AUC scores of these five symptoms in severe mucositis group were significantly higher than those in mild mucositis group and non-mucositis group(P<0.001).The OMQoL symptoms,diet,social ability and swallowing AUC scores of OMQoL in severe mucositis group and mild mucositis group were significantly lower than those in non-mucositis group.Dysphagia and sleeping difficulty had the strongest standardization coefficients in OMQoL subscale scores.Conclusion Oral mucositis is very common in elderly patients undergoing radiotherapy and chemotherapy.The related symptom may have profound impacts on patient’s quality of life and level of psychological distress.
作者
杨利锋
寇惠宁
王敏
YANG Li-feng;KOU Hui-ning;WANG Min(Department of Stomatology,Tongchuan City Maternal and Child Health Care,Tongchuan 727007,China)
出处
《北京口腔医学》
CAS
2019年第6期334-338,共5页
Beijing Journal of Stomatology
关键词
口腔黏膜炎
生活质量
老年患者
放化疗
Oral mucositis
Quality of life
Elderly patients
Radiation and chemotherapy
