摘要
磷是重要的生命元素之一,参与生命活动的各种生化反应进程。L-氨基酸是组成蛋白质的基本结构单元,氨基酸的N-磷酸化,使氨基酸分子被激活,成为一种"微型活化酶",可以发生多种生化反应,比如成肽反应。丝组二肽(L-丝氨酰-L-组氨酸)就是在N-磷酸化氨基酸的成肽反应过程中产生,并发现是具有多种生物酶活性的最小的功能肽,是现代水解酶的原始进化雏形。本文详细回顾了从N-磷酸化氨基酸到丝组二肽发现的研究历程,有痛苦、有迷茫,也有欢喜,充分体现了科学探索的魅力所在。
Phosphorus is one of the important elements for life, which participates in various biochemical processes. L-Amino acids are the basic structural units of proteins. N-phosphorylation of amino acids makes them be activated and become one kind of "micro activating enzyme", which possesses a variety of biochemical reaction activities, such as peptide formation. Based on the peptide formation reaction of N-phosphoryl amino acids, L-seryl-L-histidine dipeptide(Seryl-histidine dipeptide) is produced and found that it is the smallest functional peptide with a variety of biological enzyme activities. Seryl-histidine dipeptide could be regarded as the original evolution prototype of modern hydrolytic enzyme. This paper reviews the research process from N-phosphoryl amino acids to the discovery of serylhistidine dipeptide in detail. There are pain, confusion and joy, which fully embodies the charm of scientific exploration.
作者
赵玉芬
ZHAO Yufen(College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian Province,P.R.China;Institute of Drug Discovery Technology,Ningbo University,Ningbo 315211,Zhejiang Province,P.R.China)
出处
《大学化学》
CAS
2019年第12期86-90,共5页
University Chemistry
基金
国家自然科学基金(21778042,91856126)
关键词
磷
磷酰化氨基酸
丝组二肽
Phosphorus
N-phosphoryl-amino acids
Seryl-histidine dipeptide
