摘要
通过查阅近10年文献,对天然药物抗抑郁按活性成分进行归纳和整理,发现天然药物抗抑郁活性成分主要包括黄酮类、生物碱类、皂苷类及挥发油类等,而相关药物集中在芸香科、百合科、豆科、茄科、伞形科、茜草科及五加科等科属,并对含有各活性成分的药物作用机制进行了分析和总结,以期为筛选抗抑郁新药、新的作用靶点提供依据。
This article refers to the related literatures of antidepressant of natural medicines in recent 10 years.It was found that the antidepressant active ingredients of natural medicines mainly include flavonoids,alkaloids,saponins and volatile oils,while the related traditional Chinese medicines were concentrated on Rutaceae,Liliaceae,Leguminosae,Solanaceae,Umbelliferae,Rubiaceae and Acanthopanaceae.The mechanism of action of natural medicines was analyzed and summarized in order to provide a basis for screening new antidepressant drugs and new target in further research.
作者
王婷
孙静莹
王云
吕敏
周霞
万军
WANG Ting;SUN Jingying;WANG Yun;LYU Min;ZHOU Xia;WAN Jun(College of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China)
出处
《广东药科大学学报》
CAS
2019年第6期853-857,共5页
Journal of Guangdong Pharmaceutical University
基金
四川省大学生科研创新训练计划项目(2019166)
关键词
抑郁症
天然药物
活性成分
机制
进展
major depression disorder
natural medicines
active components
mechanisms
research progress
