摘要
目的观察芪参益气滴丸对射血分数保留心力衰竭的临床疗效。方法将就诊于保定市第一中心医院的180例射血分数保留心力衰竭患者随机分为常规组(n=90,西药常规治疗)和治疗组(n=90,西药常规治疗加用芪参益气滴丸),记录两组患者治疗前、治疗6个月后的血浆氨基末端脑钠肽前体(NT-proBNP)水平、6分钟步行距离(6-MWT)、舒张早期二尖瓣血流速度峰值与舒张晚期二尖瓣血流速度峰值的比值(E/A值)、明尼苏达心力衰竭生活质量量表评分(MLHFQ评分)的情况。结果最终169例患者纳入评估,其中常规组81例,治疗组88例,随访结束后,治疗组的NT-proBNP水平、MLHFQ评分均低于常规组,E/A值、6-MWT均高于常规组(P<0.05)。未见与试验药物明显相关的严重不良反应。结论芪参益气滴丸可以明显改善射血分数保留心力衰竭患者心脏的舒张功能、提高运动耐量及生活质量。
Objective To observe the clinical efficacy of Qishenyiqi dropping pill on heart failure with preservedejection fraction.Methods A total of 180 patients who suffer from heart failure with preserved ejection fraction were randomly divided into the conventional therapy group(90 cases,with routine treatment)and the treatment group(90 cases,with routine treatment accompanied by Qishenyiqi dropping pill).NT-proBNP,6-MWT,MLHFQ and E/A were recorded before treatment and after the treatment of 6 months.Results Totally 169 patients were included,including 88 cases in treatment group and 81 cases in conventional therapy group.After 6 months of follow-up,the NT-proBNP and MLHFQ of treatment group were lower than those of conventional therapy group(P<0.05).The E/A and 6-MWT of treatment group were higher than those of conventional therapy group(P<0.05).No serious adverse reactions were observed.Conclusion Qishenyiqi dropping pill can obviously improve cardiac diastolic function,exercise tolerance and life quality in heart failure patients with preserved ejection fraction.
作者
张凯旋
耿巍
姜一鸣
王学硕
侯雪娜
Zhang Kaixuan;Geng Wei;Jiang Yiming;Wang Xueshuo;Hou Xuena(Department of Cardiology,Chengde Medical University,Chengde 067000,China;Department of Cardiology,Baoding No.1 Central Hospital,Baoding 071000,China)
出处
《临床荟萃》
CAS
2019年第11期995-998,共4页
Clinical Focus
