摘要
目的研究米索前列醇溶液在妊娠晚期引产中的效果及其对雌激素水平及围产结局的影响。方法将我院收治的110例晚期妊娠产妇根据随机数表法分为观察组与对照组,各55例。观察组口服米索前列醇,对照组静脉滴注催产素。比较两组的应用效果。结果观察组的引产成功率、阴道分娩率均显著高于对照组(P<0.05)。观察组产妇的第一产程、第二产程、第三产程及总产程时间均显著短于对照组,产后出血量显著少于对照组(P<0.05);两组的新生儿体重比较,差异无统计学意义(P>0.05);观察组的新生儿Apgar评分显著高于对照组(P<0.05)。产后3、5、7 d,观察组与对照组的E2、E、E3水平比较,差异无统计学意义(P>0.05);产后3 d,两组的E2、E、E3水平均低于产后5、7 d(P<0.05);产后5 d,两组的E2、E、E3水平均低于产后7 d(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论米索前列醇溶液应用于妊娠晚期引产能够提高产妇的引产成功率及雌激素水平,且用药安全性高,值得临床推广应用。
Objective To study the effect of misoprostol solution on induced labor in late pregnancy and its influences on estrogen level and perinatal outcome.Methods A total of 110 cases of late pregnant women admitted in our hospital were divided into observation group and control group according to the random number table method,with 55 cases in each group.The observation group was given misoprostol solution,and the control group was given oxytocin intravenously.The application effects of two groups were compared.Results The success rates of induced labor and vaginal delivery in the observation group were significantly higher than those in the control group(P<0.05).The time of the first stage,the second stage,the third stage and the total stage of labor in the observation group were significantly shorter than those in the control group,and the amount of postpartum hemorrhage was significantly less than that in the control group(P<0.05);there was no significant difference in weight of newborn between the two groups(P>0.05);the Apgar score of newborn in the observation group was significantly higher than that in the control group(P<0.05).On the 3rd,5th and 7th day of postpartum,there was no significant difference in the levels of E2,E and E3 between the observation group and the control group(P>0.05);on the 3rd day of postpartum,the levels of E2,E and E3 in the two groups were lower than those on the 5th and 7th day of postpartum(P<0.05);on the 5th day of postpartum,the levels of E2,E and E3 in the two groups were lower than those on the 7th day of postpartum(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of misoprostol solution on induced labor in late pregnancy can improve the success rate of induced labor and the level of estrogen,and the drug safety is high,which is worthy of clinical promotion and application.
作者
李蓓
LI Bei(Xi'an Gaoling District Hospital,Xi'an 710200,China)
出处
《临床医学研究与实践》
2020年第1期151-153,共3页
Clinical Research and Practice
关键词
米索前列醇
妊娠晚期
引产
雌激素
misoprostol
late pregnancy
induced labor
estrogen
