摘要
目的探究急性脑梗死患者应用阿替普酶和尿激酶静脉溶栓治疗对患者神经功能、精神状态的影响。方法将我院2016年1月至2018年12月收治的95例急性脑梗死患者按随机原则分为A组(48例)和B组(47例),A组接受阿替普酶静脉溶栓治疗,B组接受尿激酶静脉溶栓治疗。比较两组治疗效果。结果治疗后,A组NSE、8-OHdG、MDA、S100β水平均低于B组(P<0.05);治疗后1、2周,A组MMSE评分均高于B组(P<0.05);治疗后2周、3个月,A组生活自理能力评分均高于B组(P<0.05)。结论阿替普酶静脉溶栓治疗急性脑梗死疗效较好,可促进患者神经功能恢复,改善患者精神状态,增强其生活自理能力。
Objective To explore the effect of intravenous thrombolysis with alteplase and urokinase on neurological function and mental status in patients with acute cerebral infarction.Methods Ninety-five patients with acute cerebral infarction admitted in our hospital from January 2016 to December 2018 were randomly divided into group A(48 cases)and group B(47 cases).The group A received intravenous thrombolysis with alteplase,and the group B received intravenous thrombolysis with urokinase.The therapeutic effects of the two groups were compared.Results After treatment,the levels of NSE,8-OHdG,MDA,and S100茁in the group A were lower than those in the group B(P<0.05);after 1 and 2 week of treatment,the MMSE scores in the group A were higher than those in the group B(P<0.05);after 2 weeks and 3 months of treatment,the activity of daily life scores in the group A were higher than those in the group B(P<0.05).Conclusion Intravenous thrombolysis with alteplase is effective in the treatment of acute cerebral infarction,which can promote the recovery of neurological function,improve the mental status of patients and enhance their activity of daily life.
作者
季秀丽
杨武军
JI Xiu-li;YANG Wu-jun(Xi'an North Hospital,Xi'an 710043,China)
出处
《临床医学研究与实践》
2020年第1期63-64,共2页
Clinical Research and Practice
关键词
阿替普酶
尿激酶
静脉溶栓
急性脑梗死
alteplase
urokinase
intravenous thrombolysis
acute cerebral infarction
