摘要
目的探讨腺苷A2a受体(A2aR)在胃间质瘤组织中的表达情况及其临床意义。方法应用免疫组织化学染色法,检测2012年至2017年9月徐州医科大学附属医院149例胃间质瘤组织及85例瘤旁正常组织中A2aR的表达,结合病人的临床病理资料,并分析A2aR的表达与病人预后的关系。结果A2aR在肿瘤组织中表达的阳性率为51.0%,明显高于瘤旁正常组织的31.8%,差异有统计学意义(P=0.004);A2aR的表达与肿瘤的核分裂象、危险度分级以及肿瘤是否坏死相关(P=0.002、0.010、0.013),而与其他的临床病理因素无关(P>0.05);单因素生存分析结果表明核分裂象、肿瘤大小、危险度分级、肿瘤是否坏死以及A2aR表达水平均为影响胃间质瘤病人预后的重要因素(P=0.046、<0.001、<0.001、0.005、0.002);COX多因素分析显示危险度分级、肿瘤是否坏死,以及A2aR表达是影响病人预后的独立危险因素(P=0.001、0.021、0.039)。结论A2aR高表达可能促进胃间质瘤的发生发展,并提示病人的不良预后,A2aR可能是预测胃间质瘤预后的一个新的标志物,并且有望成为其治疗的潜在靶点。
Objective To explore the expression of adenosine A2a receptor(A2aR)in gastric stromal tumor tissues and its clinical significance.Methods Immunohistochemical staining were adopted to detect the expression of A2aR in 149 gastric stromal tumor tissues and 85 para⁃tumor normal tissues in The Affiliated Hospital of Xuzhou Medical University from January 2012 to September 2017.Meanwhile,the relationship between the expression of A2aR and the prognosis of the patients were analyzed.Results The positive rate of A2aR expression in tumor tissues was 51.0%,which was significantly higher than 31.8%of normal adjacent tissues(P=0.004).The expression of A2aR was correlated with the mitotic index(P=0.002),tumor risk classification(P=0.010)and tu⁃mor necrosis(P=0.013),however,not correlated with other clinicopathological factors(P>0.05).The results of univariate survival analysis indicated that the mitotic index(P=0.046),tumor size(P<0.001),tumor risk classification(P<0.001),tumor necrosis(P=0.005)and A2aR expression(P=0.002)were the important factors affecting the prognosis of patients with gastric stromal tu⁃mor.COX multivariate survival analysis showed that tumor risk classification(P=0.001),tumor necrosis(P=0.021),and A2aR ex⁃pression(P=0.039)were independent factors influencing patients’prognosis.Conclusions The high expression of A2aR may promote the generation and development of gastric stromal tumors and indicate a poor prognosis.A2aR is expected to be a promis⁃ing therapeutic target of gastric stromal tumors.
作者
吴兆映
樊瑞智
江涛
史沛聪
时林森
宋军
WU Zhaoying;FAN Ruizhi;JIANG Tao;SHI Peicong;SHI Linsen;SONG Jun(Graduated School of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China;Department of Gastrointestinal Surgery,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China)
出处
《安徽医药》
CAS
2020年第1期99-102,共4页
Anhui Medical and Pharmaceutical Journal
基金
江苏省“六个一工程”（LGY2017093）
江苏省研究生实践创新计划（SJCX0709)
关键词
胃肿瘤
受体
腺苷A2
免疫组织化学
病理学
临床
预后
Stomach neoplasms
Receptors
adenosine A2
Immunohistochemistry
Pathology
clinical
Prognosis
