摘要
目的:探讨维持性血液透析(MHD)患者握力与心血管事件危险因素的相关性。方法:收集2016年3月至2018年9月在广西河池市人民医院肾内科行规律透析治疗的124例患者的临床资料,测量其握力,根据握力情况将MHD患者分为低握力组和高握力组,比较两组患者的临床资料、心血管事件危险因素及超声心动图指标,并分析MHD患者握力与心血管事件相关危险因素指标的关系。结果:124例MHD患者平均握力(22.95±7.81)kg。两组患者吸烟率、收缩压、血尿酸、同型半胱氨酸、全段甲状旁腺激素(iPTH)、氨基末端脑钠肽前体(NT-proBNP)、血清心肌肌钙蛋白T(cTnT)、血红蛋白、前白蛋白、左心室心肌质量指数(LVMI)、左心室肥厚(LVH)、左心室射血分数(LVEF)比较,差异均有统计学意义(均P<0.05)。MHD患者握力与吸烟率、收缩压、合并糖尿病、尿酸、血清同型半胱氨酸、iPTH、NT-proBNP、cTnT、LVMI呈负相关关系(均P<0.05),与血红蛋白、前白蛋白、LVEF呈正相关关系(均P<0.05)。结论:MHD患者握力与心血管事件危险因素相关,将握力纳入MHD患者心血管事件风险的评估体系中可能具有很好的应用价值。
Objective:To investigate the correlation between handgrip strength and cardiovascular event risk factors in maintenance hemodialysis(MHD)patients.Methods:The clinical data of 124 patients who underwent regular dialysis in Department of Nephrology of Hechi People's Hospital from March 2016 to September 2018 were collected,and their handgrip strength was measured.According to handgrip strength,MHD patients were divided into low handgrip strength group and high handgrip strength group.The clinical data,cardiovascular event risk factors and echocardiographic indexes of the two groups were compared.Spearman correlation analysis was used to explore the relationship between handgrip strength and cardiovascular risk factors.Results:The average handgrip strength of 124 MHD patients was(22.95±7.81)kg.The smoking rate,systolic blood pressure,blood uric acid,homocysteine,intact parathyroid hormone(iPTH)and amino-terminal brain natriuretic peptide precursor(NT-proBNP),serum cardiac troponin T(cTnT),hemoglobin,albumin,left ventricular myocardial mass index(LVMI),left ventricular hypertrophy(LVH)and left ventricular ejection fraction(LVEF)were statistically significant between the two groups(P<0.05).Handgrip strength in MHD patients was negatively correlated with smoking rate,systolic blood pressure,diabetes mellitus,uric acid,homocysteine,iPTH,NT-proBNP,cTnT and LVMI,while positively correlated with hemoglobin,prealbumin and LVEF(P<0.05).Conclusion:The handgrip strength of MHD patients is related to cardiovascular event risk factors.It may be of great value to incorporate handgrip strength into the cardiovascular event risk assessment system in MHD patients.
作者
蒙如庆
胡美玲
覃勋
曾秋锦
岑吉
王晓玉
韦宁荣
Meng Ruqing;Hu Meiling;Qin Xun;Zeng Qiujin;Cen Ji;Wang Xiaoyu;Wei Ningrong(Department of Nephrology,The People's Hospital of Hechi,Hechi 547000,China;Yibin First People's Hospital,Yibin 644000,China)
出处
《广西医科大学学报》
CAS
2019年第12期1937-1941,共5页
Journal of Guangxi Medical University
基金
广西河池市科学研究与技术开发计划资助项目(No.河科推1623-1)
