摘要
目的探讨名老中医赵坤教授含附子处方用药规律。方法在构建处方数据库的基础上,应用关联规则等研究方法,分析含附子处方中单味药物频次、药物组合频次、关联规则与核心药物组合等。结果含附子处方在治疗喘证、哮病、咳嗽、感冒等病证中常用,高频次药物包括附子、麻黄、款冬花、鱼腥草、杏仁、芦根、石膏等,高频次药物组合包括“附子、麻黄”“附子、赤芍”“附子、太子参”等,置信度≥0.9的关联规则包括“附子→麻黄”“附子→款冬花”“赤芍→附子、款冬花”“白芍→麻黄、附子”等,治疗喘证、哮病、咳嗽、感冒的关联规则核心药物组合与麻黄附子细辛汤和小青龙汤有一定相似性。结论赵坤教授含附子处方广泛用于小儿肺系病证,处方用药较为集中,组方法度清晰。
Objective To explore the medication rule of famous veteran doctor of TCM-Zhao Kun-in prescription containing Aconiti lateralis radix praeparata.Methods Based on the establishment of prescription database, the method of association rules was used to analyze the following items in the prescriptions containing Aconiti laterlis radix praeparata, including the frequency of single drug, frequency of drug combination, the association rules and the core drug combinations.Results The prescriptions containing Aconiti lateralis radix praeparata were commonly used for treating asthma, cough and common cold. The drugs with highest frequency were Aconiti lateralis radix praeparata, Ephedrae herba, Farfarae flos, Houttuynia cordata thunb, Armeniacae semen amarum, Phragmitis rhizoma, Gypsum fibrosum and so on. The drug combinations with highest frequency were ’Aconiti lateralis radix praeparata and Ephedrae herba’, ’Aconiti lateralis radix praeparata and Paeoniae radix rubra’, and ’Aconiti lateralis radix praeparata and Pseudostellariae radix’. The drug association rules with the confidence being more than 0.9 were ’Aconiti lateralis radix praeparata→Ephedrae herba’,’Aconiti lateralis radix praeparata→Farfarae flos’, ’Paeoniae radix rubra→Aconiti lateralis radix praeparata’, and’Paeoniae radix alba→Ephedrae herba, Aconiti lateralis radix praeparata’, and so on. The core drug combinations of association rules for treating asthma, cough and common cold had some similarities to Mahuang Fuzi Xixin decoction and Xiaoqinglong decoction.Conclusion The prescriptions containing Aconiti lateralis radix praeparata developed by Pro. Zhao are widely used in pediatric pulmonary disease syndrome. The prescription medication is more concentrated, and the combination method is clear.
作者
王艳会
宋桂华
赵坤
WANG Yanhui;SONG Guihua;ZHAO Kun(Henan University of Traditional Chinese Medicine, Zhengzhou 450009,China)
出处
《中国中西医结合儿科学》
2019年第6期461-464,共4页
Chinese Pediatrics of Integrated Traditional and Western Medicine
基金
河南省特色学科中医学学科建设项目(STS-ZYX-2017012)
国家自然科学基金面上项目(81873338,81473728)
河南省中医药科学研究专项课题(2018JDZX117)
全国名老中医传承工作室建设项目(CZ0008)
关键词
附子
数据挖掘
关联规则
Aconiti lateralis radix praeparata
Data mining
Association rules
