摘要
周围神经损伤后再生常会出现错配、卷曲及迷乱等新生轴突无序再生的情况,这是限制周围神经损伤后有效再生的重要原因之一,因此实现周围神经损伤后的有序再生,有助于提高再生的效率与功能恢复。硫酸软骨素蛋白多糖(CSPGs)作为传统的轴突再生抑制性分子,在周围神经系统正常发育过程中具有重要作用。本文从CSPGs的分类、作用特点及其时空分布等方面来探讨其在促周围神经有序再生过程中所扮演的角色及应用转化的可能性,有助于增加轴突再生数量的神经移植物的设计,进一步指导周围神经移植物的仿生构建,从而促进周围神经损伤后的有序及有效再生。
It is difficult for peripheral nerves to achieve effective and orderly regeneration after injury for there are always mismatched,curly and disorderly newborn axons.Chondroitin sulfate proteoglycan(CSPGs),a kind of widespread extracellular matrix generally considered to inhibit peripheral nerve regeneration,may play an important role in promoting orderly regeneration of axons depending on its classification,physiological characteristics and spatial and temporal distribution as well.Complementing traditional modes of regenerating axons,its flexible applications may benefit biomimetic construction of peripheral nerve grafts that purely increase the number of axons and thus promote orderly and effective regeneration after peripheral nerve lesions.
作者
何富林
杨东
朱庆棠
He Fulin;Yang Dong;Zhu Qingtang(Department of Microsurgery and Orthopedic Trauma,The First Affiliated Hospital to Sun Yat-sen University,Center for Peripheral Nerve Tissue Engineering and Technology Research,Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication,Guangzhou 510080,China;Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Centre,Guangzhou 510060,China)
出处
《中华创伤骨科杂志》
CAS
CSCD
北大核心
2019年第12期1097-1100,共4页
Chinese Journal of Orthopaedic Trauma
基金
国家重点研发计划(2016YFC1101603)
国家自然科学基金(31670986)
广东省科技计划项目(2014B020227001,2017A050501017)
广州市科技计划项目(201807010082)。
关键词
蛋白硫酸软骨素类
周围神经
神经再生
Proteochondroitin sulfates
Peripheral nerves
Nerve regeneration
