摘要
以纳米碳球和十六烷基三甲基溴化铵(CTAB)为双模板合成了具有介孔核-壳结构的纳米复合材料;并通过刻蚀法,制备了磁性介孔纳米空心球(HMNPs);在交联剂1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDC)和N-羟基硫代琥珀酰亚胺(NHS)的作用下,制备了氧化石墨烯(GO)功能化的磁性介孔纳米空心球(HMNPs-GO)。利用红外光谱(FT-IR)、X-射线粉末衍射(XRD)、拉曼光谱(Raman)、扫描电镜(SEM)、透射电镜(TEM)和振动样品磁强计(VSM)等方法进行了表征。通过研究HMNPs-GO对藤黄酸(GA)的吸附等温线,得出HMNPs-GO对GA的吸附主要为两者之间的π-π堆积,且属于Freundlich吸附。同时,基于Bhaskar模型和准一级、准二级动力学模型,分别探讨了HMNPs-GO中GA药物分子的扩散机理和缓释动力学,得出GA在HMNPs-GO中的缓释具有pH依赖性,且在不同pH下的缓释更适合于准二级动力学模型。
A mesoporous shell structure was synthesized using carbon spheres and cetyltrimethylammonium bromide(CTAB) as dual templates, and hollow magnetic nanoparticles(HMNPs) were subsequently prepared by etching. Hollow magnetic nanoparticles functionalized by graphene oxide(HMNPs-GO) were synthesized via the functionalization of HMNPs with NH2 groups and the activation of carboxyl groups of graphene oxide by N-ethyl-NO-(3-(dimethylamino)propyl) carbodiimide/N-hydroxysuccinimide(EDC/NHS). HMNPs and HMNPs-GO were characterized by Fourier transform infrared(FT-IR) spectroscopy, X-ray diffraction(XRD), Raman, scanning electron microscopy(SEM), transmission electron microscopy(TEM) and vibrating sample magnetometer(VSM). Upon the investigations on the adsorption isotherm of HMNPs-GO, it was found that the adsorption of GA by HMNPs-GO was mainly attributed to the π-π accumulation between each other and was refer to Freundlich adsorption. The diffusion mechanism and release kinetics of GA in HMNPs-GO were studied based on Bhaskar model, quasi-first-order, and quasi-second-order kinetic model, respectively. The release of GA showed pH dependence in HMNPs-GO, and the sustained release at different pH followed the quasi-second-order dynamics model.
作者
殷红霞
杨宇翔
黄艳
赵怡
倪超英
YIN Hongxia;YANG Yuxiang;HUANG Yan;ZHAO Yi;NI Chaoying(School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China;Department of Materials Science and Engineering,University of Delaware,DE 19716,USA)
出处
《华东理工大学学报（自然科学版）》
CAS
CSCD
北大核心
2019年第6期873-882,共10页
Journal of East China University of Science and Technology
基金
国家自然科学基金项目（20577010,20971043）
关键词
磁性空心球
氧化石墨烯
药物缓释
hollow magnetic nanoparticles
graphene oxide
drug release
