摘要
软骨细胞能够承受复杂的机械应力负荷,可对变化的机械负荷进行识别并作出灵敏和准确的反应,以维持软骨的稳态。机械转导通路阻断可能导致软骨破坏,从而导致骨关节炎相关疾病。机械门控离子通道在软骨细胞的机械转导中发挥着重要的功能。研究表明,Piezo1离子通道蛋白介导的机械转导途径能够调节关节软骨细胞损伤,保护软骨细胞免受机械诱导的细胞凋亡。该文通过查阅Piezo1蛋白与软骨细胞相关文献,阐述机械应力刺激下Piezo1对软骨细胞凋亡的调控作用,为骨关节炎等软骨细胞相关疾病的治疗研究提供依据。
Chondrocytes experience a complex mechanical environment and respond to changing mechanical loads sensitively and accurately in order to maintain cartilage homeostasis.If mechanotransduction pathways are disrupted,the cartilage may become damaged,which can result in osteoarthritis and other painful joint diseases.Mechanically gated ion channels are of functional importance in chondrocyte mechanotransduction.Some studies showed that the Piezo1-mediated mechanotransduction pathway modulates mechanical load-mediated chondrocyte injury,protecting articular chondrocytes from mechanically induced cell death.In this paper,we summarized the regulation of Piezo1 on chondrocytes apoptosis under mechanical stress stimulation by reviewing the literature on Piezo1 protein and chondrocytes,which can provide a basis for the treatment of chondrocyte-related diseases such as osteoarthritis.
作者
周绪昌
杜玉香
张玲莉
ZHOU Xuchang;DU Yuxiang;ZHANG Lingli(Shanghai University of Sport,Shanghai 200438,China;South China Normal University,Guangzhou 510631,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第9期1832-1836,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金青年科学基金(批准号:81902298)资助的课题~~
