摘要
与传统成像技术相比,荧光成像因具有更高的安全性、更好的空间分辨率和实时性等优点而被广泛应用于临床肿瘤检测和术中导航。目前应用较多的荧光探针主要包括持续发光型和环境响应型,其中环境响应型探针的灵敏度与特异性更好,且可产生较高的信噪比,因而作为应用首选。环境响应型探针主要分为3种,酶激活的探针、pH敏感型探针和乏氧响应型探针。该文总结了环境响应型荧光探针最新的研究进展,并探讨其在肿瘤检测和肿瘤术中导航应用中的潜在价值。
Unlike conventional imaging technologies,fluorescent imaging benefits from its safety,high-spatial resolution and real-time capability,which make it a highly adoptable imaging method for tumor detection and image-guided surgery in clinics.There are two types of fluorescent probes,including always-on type and environment-responsive type,wherein environment-responsive probes are preferred due to higher target-to-background ratios,which can improve sensitivity and specificity.The environment-responsive probes include enzyme-reactive probes,pH-sensitive probes and hypoxia responsive probes.This review summarizes recent progress in environment-responsive probes,and discusses their potentials in tumor detection and image-guided surgery.
作者
朱靖
楚成超
刘刚
Zhu Jing;Chu Chengchao;Liu Gang(Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China)
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2019年第11期694-697,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
国家重点研发计划 (2017YFA0205201)。
关键词
分子探针
荧光
肿瘤微环境
酶类
氢离子浓度
细胞低氧
发展趋势
Molecular probes
Fluorescence
Tumor microenvironment
Enzymes
Hydrogen-ion concentration
Cell hypoxia
Trends
