摘要
目的分析白细胞介素-15(IL-15)表达水平及其与脊柱颈段创伤手术预后之间的关系,进一步验证IL-15对脊柱颈段创伤的监测价值。方法2016年8月-2018年4月采用定群抽样的方法选取西安市红会医院骨科收治的脊柱颈段创伤并在该院接受手术治疗的85例患者,男性49例,女性36例,平均年龄(47.25±8.96)岁。分别在术前,术后24、48、96h分4次采用ELISA法测定患者血清IL-15水平,同时采用临床症状评分及生活质量评估量表评估患者的预后状况,数据录入SPSS20.0进行统计分析。结果术前IL-15水平显著低于术后24、48、96h结果,差异有统计学意义(P<0.05),但术后24、48、96h之间的结果差异无统计学意义(P>0.05);术前IL-15水平与循环系统、泌尿系统、神经系统以及躯体和情绪功能评分存在正相关关系;术后24h检测IL-15水平与循环系统、泌尿系统、神经系统以及躯体功能评分存在正相关关系;术后48h和96h的IL-15水平均与循环系统、泌尿系统、神经系统和情绪功能评分存在正相关关系(P<0.05);脊柱颈段创伤患者血清IL-15对患者预后的预测价值的ROC曲线下面积为0.824(95%CI:0.748~0.916)。结论脊柱颈段创伤患者血清IL-15水平的急剧上升多发生于术前至术后24h,同时患者血清IL-15水平对患者预后的预测具有良好的临床诊断价值。
Objective To analyze the relationship between the expression of interleukin-15(IL-15)and the prognosis of cervical spine injury,and to further verify the value of IL-15 in the monitoring of cervical neck injury.Methods From Aug.2016 to Apr.2016,85 patients who underwent surgical treatment of the cervical spine in the Orthopedic Department of Xi’an Honghui Hospital were selected by cluster sampling.Among them were males and 36 female patients;the average age was(47.25±8.96)years old.Before operation,serum IL-15 levels were measured by ELISA at 24 h,48 h,and 96 h after surgery.The prognosis of patients was evaluated by clinical symptom score and quality of life assessment scale.The data were entered into SPSS20.0 for statistical analysis.Results The preoperative IL-15 level was significantly lower than that at 24 h,48 h and 96 h after operation.The difference was statistically significant(P<0.05),but there was no significant difference between the 24 h,48 h and 96 h postoperative results(P>0.05).Preoperative IL-15 levels were positively correlated with circulatory,urinary,nervous,and physical and emotional function scores;IL-15 levels and circulatory,urinary,nervous,and physical function scores were measured 24 h after surgery and there was a positive correlation.There was a positive correlation between IL-15 levels at 48 h and 96 h after operation and circulatory system,urinary system,nervous system and emotional function scores,all with P<0.05.The area under the ROC curve for predictive value of serum IL-15 levels in patients with cervical spine trauma for patient prognosis was 0.824(95%CI:0.748-0.916).Conclusion The sharp increase of serum IL-15 level in patients with cervical spine injury occurs mostly from preoperative to postoperative 24 h.At the same time,serum IL-15 level has a good clinical diagnostic value for predicting the prognosis of patients.
作者
孟羿彬
黄云飞
贾帅军
贺欣
李帆
刘德印
MENG Yi-bin;HUANG Yun-fei;JIA Shuai-jun;HE Xin;LI Fan;LIU De-yin(Minimally Invasive Surgery of the Spine,Xi an Honghui Hospital,Xi an 710068,China;Department of Traumatology,Xi an Honghui Hospital,Xi an 710068,China)
出处
《创伤外科杂志》
2019年第11期857-859,共3页
Journal of Traumatic Surgery
