摘要
[目的]分析幽门螺杆菌(Hp)感染与结直肠腺瘤发病的相关性及影响结直肠腺瘤发生的危险因素。[方法]回顾性收集2016年5月~2018年5月于我院内科就诊的经胃镜、结肠镜检查的确诊为结直肠腺瘤的98例患者为结直肠腺瘤组,同时收集同期经胃镜、结肠镜检查筛查未见肠道异常者92例为对照组,比较2组患者的一般资料,并通过多因素Logistic回归分析影响结直肠腺瘤发生的危险因素,并分析结直肠腺瘤与Hp感染的相关性。[结果]经趋势性χ^2检验初步筛选显示Hp感染、高脂血症病史、结肠癌家族史与结直肠腺瘤发病相关(均P<0.05);多因素Logistic回归分析结果进一步证实Hp感染、既往高脂血症和结肠癌家族史均为最终进入模型的危险因素;98例结直肠腺瘤患者中Hp感染者40例,占40.8%,非Hp感染者58例,占59.2%,结直肠腺瘤患者Hp感染者腺瘤最大径≥1 cm及高危腺瘤占比明显高于Hp未感染者(均P<0.05),不同发病部位、不同腺瘤个数及病理结果比较差异无统计学意义(均P>0.05)。[结论]Hp感染、高脂血症、结肠癌家族史均为结直肠腺瘤发生的危险因素,较大腺瘤及高危腺瘤的Hp感染率明显更高。
[Objective]To analyze the correlation between helicobacter pylori(Hp)infection and colorectal adenoma and the risk factors of colorectal adenoma.[Methods]A retrospective collection of 98 patients diagnosed with colorectal adenoma through gastroscopy and colonoscopy who were admitted to the department of gastroenterology of our hospital from May 2016 to May 2018 were included in the colorectal adenoma group.At the same time,92 patients who had no intestinal abnormalities detected by gastroscopy and colonoscopy during the same period were collected as the control group.The general data of the two groups were compared,and the risk factors of colorectal adenoma were analyzed by multivariate Logistic regression,and the correlation between colorectal adenoma and Hp infection was analyzed.[Results]Preliminary screening by trend χ^2 test showed that Hp infection,history of hyperlipidemia and family history of colon cancer were correlated with the incidence of colorectal adenoma(all P<0.05);The results of multivariate Logistic regression analysis further confirmed that Hp infection,previous hyperlipidemia and family history of colon cancer were all risk factors for eventual entry into the model;Among the 98 cases of colorectal adenoma,40 cases(40.8%)were hp-infected,and 58 cases(59.2%)were non-hp-infected,and the proportion of adenoma in patients with colorectal adenoma infected with Hp≥1 cm and high-risk adenoma was significantly higher than that in patients without Hp infection(all P<0.05).At the same time,there was no statistically significant difference in the number of different onset sites,adenomas and pathological results(all P>0.05).[Conclusion]Hp infection,hyperlipidemia,and a family history of colon cancer are all risk factors for colorectal adenoma,and the infection rate of larger adenoma and high-risk adenoma is significantly higher.
作者
陈秀艳
郭琼
陈陆俊
CHEN Xiu-yan;GUO Qiong;CHEN Lu-jun(Department of Internal Medicine,Yangzhou Friendship Hospital,Jiangsu Yangzhou 225009,China;Department of Gastroenterology,Affiliated Hospital of Suzhou University,Jiangsu,Yangzhou 215000,China)
出处
《中国中西医结合消化杂志》
CAS
2019年第11期850-853,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金青年科学基金项目(No:81301960)
关键词
幽门螺杆菌
结直肠腺瘤
危险因素
回顾性研究
helicobacter pylori
colorectal adenoma
risk factors
retrospective study
