摘要
背景:能量代谢调控2型糖尿病骨代谢是近来生命医学领域的研究热点。长期糖、脂等能量代谢的紊乱导致胰岛素抵抗,引发2型糖尿病。而沉默信息调节因子1(SIRT1)作为一种烟酰胺腺嘌呤二核苷酸(NAD+)依赖的组蛋白去乙酰化酶,是调控能量代谢关键因子,还参与骨代谢、基因转录、细胞衰老、凋亡及焦亡等。目的:分析近年来有关SIRT1在运动改善骨代谢中的作用机制的相关文献,研究其现状和研究进展。方法:在PubMed、CNKI等数据库进行检索,中文关键词:SIRT1,运动,2型糖尿病,骨形成,骨吸收;英文关键词:SIRT1,exercise,type 2 diabetes,bone formation,bone resorption。结果与结论:①成骨细胞和破骨细胞的分化和功能发挥以及相互之间的代谢平衡是保障骨代谢稳态的关键。而一旦发生紊乱将会导致骨组织形态结构退化,这也是2型糖尿病并发症骨质疏松发生的重要机制;②能量代谢紊乱是引发2型糖尿病的关键,那么SIRT1作为调控能量代谢关键因子,其可通过Wnt、转化生长因子β等途径介导成骨细胞和破骨细胞分化及功能;③近来,研究发现运动可显著改善2型糖尿病的能量代谢和骨代谢,文章从成骨细胞、破骨细胞出发,通过综述目前国内外相关研究,探究SIRT1在运动改善2型糖尿病骨代谢中的作用机制。
BACKGROUND:Energy metabolism regulates type 2 diabetes bone metabolism is a hotspot in the field of life medicine.Long-term disorders of energy metabolism such as sugar and lipids lead to insulin resistance,which triggers type 2 diabetes.Silent information regulator 1(SIRT1),a nicotinamide adenine dinucleotide-dependent histone deacetylase,is a key factor regulating energy metabolism and is involved in bone metabolism,gene transcription,cellular senescence,apoptosis and pyroptosis.OBJECTIVE:To analyze the recent literature on the mechanism of action of SIRT1 in exercise-improving bone metabolism,and to investigate its current status and research progress.METHODS:Databases of PubMed and CNKI were retrieved.The keywords were“SIRT1,exercise,type 2 diabetes,bone formation,bone resorption”in Chinese and English,respectively.RESULTS AND CONCLUSION:(1)The differentiation and function of osteoblasts and osteoclasts and the metabolic balance are the key to ensure the homeostasis of bone metabolism.In the event of a disorder,the morphological structure of the bone tissue will be degraded,which is also an important mechanism for the occurrence of osteoporosis in type 2 diabetes complications.(2)Energy metabolism disorder is critical for triggering type 2 diabetes.SIRT1,as a key factor regulating energy metabolism,can mediate osteoblast and osteoclast differentiation and function through Wnt and transforming growth factor-βpathways.(3)Recently,exercise has been shown to significantly improve the energy metabolism and bone metabolism of type 2 diabetes.Based on the osteoblasts and osteoclasts,the current researches at home and abroad are reviewed to explore the mechanism of SIRT1 in the improvement of type 2 diabetes bone metabolism.
作者
张路遥
Zhang Luyao(Department of Physical Education,Huaiyin Institute of Technology,Huaian 223003,Jiangsu Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第2期276-281,共6页
Chinese Journal of Tissue Engineering Research
