低分子量肝素钙对早发型重度子痫前期(PE)孕妇凝血功能及母儿结局的影响被引量：6

Effect of low molecular weight heparin calcium on coagulation function and maternal and child outcomes in pregnant women with early-onset severe preeclampsia (PE)

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摘要目的探讨低分子量肝素钙对早发型重度子痫前期(PE)孕妇凝血功能及母婴结局的影响。方法选择本院妇产科2017年10月至2018年9月间收治的早发型PE患者76例,随机分为对照组和观察组,各38例。对照组给予解痉、镇静、降压以及其他相应对症治疗;观察组在对照组基础上给予低分子量肝素钙治疗。比较两组治疗前后凝血功能四项指标(TT、PT、APTT、FBG)变化及母婴结局情况。结果治疗后,两组TT、PT、APTT均升高,FBG降低(P<0.05);观察组治疗后TT、PT、APTT均高于对照组,FBG低于对照组(P<0.05);两组剖宫产、非剖宫产情况比较差异无统计学意义;观察组死胎、围产儿死亡及新生儿窒息等发生情况明显少于对照组(P<0.05)。结论低分子肝素钙可显著提高早发型PE孕妇TT、PT、APTT水平,降低FBG水平,改善母婴结局,疗效显著,安全性高,值得临床推广应用。 Objective To investigate the effect of low molecular weight heparin calcium on coagulation function and maternal and infant outcomes in pregnant women with early onset severe preeclampsia(PE).Methods 76 patients with early-onset PE admitted to our gynecology and obstetrics department from October 2017 to September 2018 were divided into control group and observation group,38 cases in each group,according to the patient's medical record number.The control group was given spasmolysis,sedation,hypotension and other corresponding symptomatic treatment.The observation group was treated with low molecular weight heparin calcium on the basis of the control group.The changes of four indexes of coagulation function(TT,PT,APTT,FBG)and maternal and infant outcomes were compared between the two groups before and after treatment.Results After treatment,TT,PT and APTT increased and FBG decreased in both groups(P<0.05);TT,PT and APTT in the observation group were higher than those in the control group,while FBG was lower than those in the control group(P<0.05);there was no significant difference in cesarean section and non-cesarean section between the two groups;stillbirth,perinatal death and neonatal asphyxia in the observation group were significantly less than those in the control group(P<0.05).Conclusion Low molecular weight heparin calcium can significantly improve TT,PT and APTT levels of pregnant women with early onset PE,reduce FBG levels and improve maternal and infant outcomes.It is effective and safe,and is worthy of clinical application.

作者文小明 Wen Xiaoming(Department of Obstetrics and Gynecology,Songzi Maternal and Child Health Hospital,Songzi,Hubei,434200,China)

机构地区松滋市妇幼保健院妇产科

出处《当代医学》 2019年第28期27-29,共3页 Contemporary Medicine

关键词低分子量肝素钙重度子痫前期凝血功能母婴结局 Low molecular weight heparin calcium Severe preeclampsia Coagulation function Maternal and infant outcomes

分类号 R71 [医药卫生—妇产科学]