摘要
胰腺癌是消化系统中恶程度很高的肿瘤,早期不易诊断,临床治疗效果差,故预后也差,5年生存率仅仅约为5%。手术切除是治疗胰腺癌的一种方法,有少数病人约15%~20%的初诊患者才有手术治疗的机会,很多患者在确诊时就有局部血管浸润或远处转移病灶,不具备手术切除指征,只有姑息治疗。具备根治性手术治疗的胰腺癌病人5年生存期只有15%~20%,而且术后复发率高影响患者的生存期。胰腺癌患者的手术后高复发率与原发肿瘤的生物学特性有关,因此胰腺癌早期血管浸润或区域淋巴结转移是不能达到根治性切除主要的危险因素。近几年胰腺癌的诊治技术不断改进和提高,疗效仍然欠佳,治疗后患者的预后不理想。随着医疗水平的提高,提出了新辅助治疗的理念,对手术前的患者给予新辅助放化疗使局部肿块缩小、降期、早期杀死转移细胞,有利于手术治疗,积极改善患者预后。使肿瘤患者从新辅助治疗中获益已得到同道们的认同,对胰腺癌患者的新辅助治疗已经成为临床医生们关注的话题。现将胰腺癌新辅助治疗临床观察与体会做一阐述。
Pancreatic cancer is a highly malignant tumor in the digestive system.It is difficult to diagnose in the early stage and has poor clinical treatment and prognosis.The 5-year survival rate is only about 5%.About 15%to 20%of newly diagnosed patients have the opportunity to undergo surgery.Many patients have local vascular infiltration or distant metastatic lesions at the time of diagnosis.And there is no indication for surgical resection,but palliative treatment.The 5-year survival of patients with pancreatic cancer who have radical surgery is only 15%to 20%.And the high recurrence rate affects the survival of patients.The high recurrence rate after surgery in patients with pancreatic cancer is related to the biological characteristics of the primary tumor.Therefore,early vascular invasion or regional lymph node metastasis of pancreatic cancer is the main risk factor for radical resection.In recent years,the diagnosis and treatment of pancreatic cancer has been continuously improved,but the curative effect is still poor and the prognosis of patients after treatment is not satisfactory.With the improvement of medical level,the concept of neoadjuvant therapy has been proposed.Newly assisted radiotherapy and chemotherapy for patients before surgery can reduce the local mass and the stage,and kill the metastatic cells at an early stage,which is conducive to surgical treatment and positively improve the prognosis of patients.It has been recognized by the many people that tumor patients benefit from neoadjuvant therapy.Neoadjuvant therapy for patients with pancreatic cancer has become a concern for clinicians.This paper elaborates the clinical observation and experience of neoadjuvant therapy for pancreatic cancer.
作者
辛玉珍
XIN Yu-zhen(Department of Oncology,Qinghai Red Cross Hospital,Xining,Qinghai Province,810000 China)
出处
《系统医学》
2019年第12期192-194,共3页
Systems Medicine
关键词
胰腺癌
辅助治疗
临床观察
Pancreatic cancer
Adjuvant therapy
Clinical observation
