摘要
目的 观察酞咪哌啶酮单药或联合地塞米松治疗多发性骨髓 (MM)瘤的疗效及副作用。方法 单药组 :男 8例 ,女 1例 ,治疗起始剂量为 1 0 0mg·d- 1 ,根据患者耐受情况 ,逐渐加量 ,最高达 80 0mg·d- 1 。联合组 :男 1 1例 ,女 4例 ,剂量为 40 0mg·d- 1 左右 ,并于第 1～ 4天、9～ 1 2天 ,1 7～ 2 0天加用地塞米松 40mg·d- 1 。结果 单药组 5例患者对治疗有反应 ;完全缓解 2人。联合组 1 1例患者对治疗有反应 ;其中完全缓解或接近完全缓解 6人。
OBJECTIVE To investigate the theraputic effects and adverse reactions of thalidomide combined with dexamethasome or not in the treatment of multiple myeloma (MM).METHODS There were eight men and one woman in thalidomide alone group. The dose for each patient was 100 mg·d -1 at the begining and was increased stepwise according to the patient's tolerance with the maximum dose of 800 mg·d -1 .Eleven men and four woman were included in the combined treatment group,in which Dexamethasome (40 mg·d -1 )was used at d 1-4 ,d 9-12 ,d 17-21 when the dose of thalidomide increased to 400 mg·d -1 ,RESULTS The treating response rates were 55.6% and 73.3% for thalidomide alone group and for combination group, respectively. Both of the two groups had side effects of constipation and skin rash.CONCLUSION Both thalidomide alone or combined with dexamethasone was effective in the treatment of MM.
出处
《华西药学杂志》
CAS
CSCD
2002年第5期380-381,共2页
West China Journal of Pharmaceutical Sciences
