摘要
目的 运用灰色数学理论预测长效缓释蛋白微球的体外释药过程。方法 以复乳法制备PELA蛋白微球作为实验对象 ,根据灰色数学模型 ,借助计算机编程 ,预测PELA蛋白微球的体外释药过程。结果 预测值与实测值平均绝对误差E在 2 .3～ 4 .6之间 ,平均相对误差在 9.2 %～ 1 4 %范围内。
OBJECTIVE To predict drug release from the extended formulations by grey maths model. METHODS The grey maths model was constructed according to drug release data within shot time through computer processing and employed to forecast the BSA release from poly(D,L-lactide)-polyethylene glycol copolymer (PELA) microspheres in vitro , which were prepared by double emulsion evaporation method.RESULTS The absolute and relative errors between the factual and predicting values were 2.3 4.6 and 9.2% 14%, respectively. CONCLUSION Grey maths theory can be used to forecast drug release from the sustained and extended formulations.
出处
《华西药学杂志》
CAS
CSCD
2002年第5期332-333,共2页
West China Journal of Pharmaceutical Sciences
关键词
灰色理论
微球
预测
Grey maths theory
Microsphere
Prediction
