摘要
目的 :探讨辛伐他汀对血脂正常的稳定型心绞痛患者的抗心肌缺血作用。方法 :85例血脂正常的稳定型心绞痛患者随机分为治疗组 (常规治疗外 ,加服辛伐他汀 ,4 5例 )和对照组 (仅常规治疗 ,4 0例 ) ,于治疗前 ,治疗后 3、6和 12个月时分别行 2 4hHolter检测心肌缺血总负荷 (TIB)并记录缺血相关事件。结果 :①治疗后 6个月治疗组TIB低于对照组 ,但差异无显著性意义 (P >0 .0 5 ) ,治疗后 12个月治疗组TIB显著低于对照组 (P <0 .0 5 ) ;②治疗组的缺血相关事件明显少于对照组 (P <0 .0 5 ) ,但治疗 6个月内两组间差异无显著性意义。结论
Objective:To explore the anti myocardial ischemic effects of simvastatin on patients with stable angina pectoris and average lipid levels. Methods:Eighty five subjects were randomly divided into simvastatin group and control group. They all underwent total ischemic burden (TIB) monitoring from 24 hour ambulatory electrocardiogram recording and observation of ischemia related events before and 3, 6 and 12 months after therapy.Results:TIB in simvastatin group was lower than that in control group after 6 months of therapy, but without statistic difference between these two groups (P> 0.05 ). By the end of 12 months of therapy, TIB in simvastatin group was significantly lower than that in control group (P< 0.05 ). During the 12 months of follow up, fewer ischemia related events occurred in the simvastatin group (P< 0.05 ), which was confirmed between 6 and 12 months but not during first 6 months. Conclusion:Simvastatin can take anti myocardial ischemic effects and reduce the incidence of ischemia related events.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2002年第8期378-380,共3页
Journal of Clinical Cardiology
关键词
心绞痛
心肌缺血
辛伐他汀
Angina pectoris
Myocardial ischemia
Simvastatin
