摘要
为了探讨银杏叶提取物对中枢神经系统高级机能活动的作用 ,为临床应用银杏叶提取物治疗认知功能障碍提供实验依据 ,采用东莨菪碱所致老龄大鼠学习记忆障碍的拟老年性痴呆动物模型 ,以水迷宫和避暗实验等学习记忆行为训练及生化检测方法 ,观察用药前后动物学习记忆行为和海马乙酰胆碱及蛋白质含量的变化。实验结果显示 :银杏叶提取物呈剂量依赖性显著改善实验动物的学习记忆能力 (P<0 .0 5或 P<0 .0 1) ,并显著增加海马脑区乙酰胆碱含量(P<0 .0 5或 P<0 .0 1)。结果表明
To study the effects of extracts of ginkgo biloba leaves (EGB) on the higher nervous activities of central nervous system, and provide the experimental evidence for the therapeutic possibilities of EGB, the aged animal model with disorders of learning and memory abilities was established by using Scopolamine. By the methods of learning behavioral training (Y maze test and avoiding darkness test) and biochemistry determination, the changes of learning and memory behavior and the contents of acetylcholine and protein in the hippocampus were observed. The results showed that EGB could obviously improve the learning and memory dysfunction of the animal model in a dose dependent manner( P<0 05 or P <0 01). The content of acetylcholine in hippocampus were obviously increased by EGB in the animal model( P<0 05 or P <0 01). It was indicated that EGB could improve the learning and memory dysfunction in dementia aged rats.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2002年第5期518-521,共4页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
湖北省卫生厅资助项目 (No.WT974 39)
武汉市青年科技晨光计划资助项目 (No.2 0 0 2 5 0 0 10 2 9)
关键词
银杏叶提取物
乙酰胆碱
学习记忆障碍
extracts of ginkgo biloba leaves
acetylcholine
learning and memory dysfunction
