摘要
目的 观察原发性脑内恶性淋巴瘤 (PIML)的临床病理及免疫表型。方法 收集 1 2例 PIML的临床资料并有随访的病例 ,用单克隆抗体 LCA、L2 6、UCHL- 1、CD3 0 、CD68、S- 1 0 0蛋白及 GFAP行免疫组化染色 ,观察临床病理形态特点及免疫表型。结果 肿瘤组织形态与结内淋巴瘤基本一致 ,但无淋巴滤泡形成。瘤细胞有明显围血管现象 ,呈袖套样分布。免疫组化标记所有病例 LCA及 L2 6阳性 ,其余阴性。结论 本组 PIML均为 B细胞源性。瘤细胞分布疏密不均 ,向血管性及免疫组化 LCA阳性。
Objective To investigate the clinicopatholocal features and immunophenotypes of primary intracerebral malignant lymphoma(PIML).Methods 12 cases of PIML were collected with clinical and follow up data to observe the clinicopathological features and immunophenotypes.All cases were analysed by means of immunohistochemical staining using such monoclonal antibodies as LCA,L 26 ,UCHL 1,CD 30 ,CD 68 ,S 100,and GFAP.Results The morphology of all cases of PCNSL resembled intranodal lymphomas,but no lymphoid follicles were found.Tumor cells presented an appearance of accumulating around blood vessels like muff.LCA and L 26 were positive in all cases ,but other monoclonal antibodies showed negative.Conclusions This group of PIML were all B cell lymphomas.Tumor cells presenting such features as inhomogenous distribution,accumulating around blood vessels,LCA positive while GFAP negative were helpful in diagnosis of PIML.
出处
《中国误诊学杂志》
CAS
2002年第11期1614-1616,共3页
Chinese Journal of Misdiagnostics
关键词
脑肿瘤
病理学
淋巴瘤
诊断
免疫组织化学
Brain neoplasms/pathology
Lymphoma/diagnosis
Immunohistochemistry
