摘要
目的 :评价单用常规剂量贝那普利与小剂量贝那普利和小剂量伊贝沙坦联用治疗轻、中度高血压病人的降压幅度、血管活性物质的变化及不良反应。方法 :采用随机对照研究方法 ,治疗组贝那普利 5mg /日加伊贝沙坦 75mg /日× 8wk ,对照组贝那普利 10mg /日× 8wk。两组均于治疗前及治疗后 1、4、8wk各测血压一次 ,并与治疗前血压相比较求出血压下降幅度。治疗前及治疗后 4、8wk各测定一次血浆肾上腺素 (E )、去甲肾上腺素 (NE )、醛固酮 (ALD )、血管紧张素Ⅱ (AngⅡ )和肾素 (Renin )。 结果 :与治疗前相比较 ,治疗组第 8wk收缩压下降幅度为 2 4.5 3± 4.2 6mmHg ,舒张压的下降幅度为 13.12± 2 .74mmHg ;对照组第 8wk收缩压下降幅度为 13.91± 2 .6 9mmHg ,舒张压的下降幅度为 11.82± 2 .31mmHg (P <0 .0 5 )。治疗后 ,E、NE、ALD水平两组无差异 ,Renin、AngⅡ治疗组较对照组增高。不良反应发生率治疗组 2 % ,对照组 14% (P <0 .0 1)。结论 :初步观察小剂量贝那普利和小剂量伊贝沙坦合用较常规剂量贝那普利能提高疗效 。
OBJECTIVE:The aim of this study was to evaluate the curative effects and side effects and plasma active substance variation of benazepril (a kind of angiotensin-converting enzyme inhibitor,ACEI) and bennazepril plus irbesartan (a kind of AngiotensinⅡreceptor antagonist) at lower dosage in treating patients with slight or moderate hypertension. METHOD: 100 cases of patients with slight or moderate hypertension were randomized into 2 groups of 50 patients, each: benazepril(10mg per day for 8wk) group(BEN) and benazepril(5mg per day for 8wk) plus irbesartan(75mg per day for 8 wk) group(BIR) respectively. The efficiency of lowering blood pressure and side effects were observed after 1week?4 weeks and 8 weeks of treatment. The plasma epinephrine(E)?noradrenalin(NE)?aldosterone(ALD)?angiotensin Ⅱ(AngⅡ)and renin were also detected before and after 4 weeks and 8 weeks of therapy.RESULTS:The results described as following: ①compared with the BEN, the declined level of systolic blood pressure(24.53+/-4.26mmHg vs 13.91+/-2.69mmHg) and diastolic blood pressure (13.12+/-2.74mmHg vs 11.82+/-2.31mmHg)were very significantly in BIR after 8 weeks of therapy(P<0.05). ②The E?NE and ALD level were similar before and after therapy in both two groups(P>0.05). But the renin and AngⅡlevel (3.78+/-1.21ng/ml,165.43+/-51.82pg/ml, respectively)in BIR were significantly higher than that in BEN(2.13+/-1.01 ng/ml, 131.67+/-67.40pg/ml, respectively).③The side effects ratio was significantly lower in BIR(2%) than that in BEN(14%).CONCLUSION:According to our study we conclude that : combined use of benazepril and irbesartan at lower dosage showed a therapeutic effect better and less side-effects than that of benazepril used at regular dosage.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2002年第5期421-423,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
贝那普利
伊贝沙坦
治疗
高血压
临床比较
Hypertension Angiotensin-converting enzyme inhibitor AngiotensinⅡreceptor antagonist Benazepril Irbesartan
