摘要
目的 观察分析了 6 81例 2 HRS(E) Z/ 4 HR方案对 HBV- M阳性患者头 3个月强化治疗期对肝功能的影响。方法 对12 8例慢性乙肝病毒阳性携带者 HBs Ag(+) ( 组 )以及 87例活动性肝炎患者 ( 组 )与 4 6 6例 HBV- M阴性 ( 组 )肺结核患者在接受 2 HRS(E) Z/ 4 HR方案抗结核治疗时的肝功能异常。结果 肝损害发生率分别为 : 组 2 7例 (2 1.0 9% ) , 组 4 4例 (5 0 .4 8% ) , 组 6 9例 (14 .8% )。 组与 组、 组之间经统计学处理均有显著差异 (p<0 .0 1)。而 组与 组之间无明显差异 (p>0 .0 5 )。结论 乙肝病毒阳性健康携带者合并肺结核患者 ,可予有效抗结核治疗 ,但活动性肺结核患者在接受 2 HRS(E) Z/ 4 HR方案抗结核治疗时 ,肝损率较高且程度严重 。
objects To evaluate the effect of regimen of 2HRS(E)Z/2HR on the liver function of the 681 pulmonary tuberculosis patients accompasined with positive markers of postive HBVM. Method In HBVM The liver function of the pulmonary tuberculosis patients with positive markers of HbsAg(Ⅰgroups)and active hepatitis(Ⅱ groups) who were given the treatment of regimen of 2HRS(E)Z/4HR,was restrospectively analyzed.Simulariously,the results have been compared with those of negative markers of viral hepatitis patients(Ⅲgroups).Results The incidence of live damage in group Ⅱwas 50.48%,higher than in group Ⅰ(21.09%) and group Ⅲ(14.8%) significant difference was found between the Ⅱ groups and groups Ⅰ,Ⅱ(p<0.01).Conclusion The regimen of 2HRS(E)Z/4HR had a sight damage to the liver function of the pulmonary tuberculosis patients with positive markers of HBsAg,but incidence of liver injury in active hepatitis is higher and server.
出处
《临床肺科杂志》
2002年第4期42-43,共2页
Journal of Clinical Pulmonary Medicine
