摘要
以试管两倍稀释法测得体外氟甲砜霉素 (florfenicol)及对照药物恩诺沙星对禽败血支原体 (MG)的最小抑菌质量浓度分别为 1.2 5、0 .0 195 mg/ L。体内药效试验表明 ,氟甲砜霉素以 30 0、40 0、5 0 0 mg/ kg饲料混饲给药 ,连用 5 d,对实验性感染 MG的鸡具有显著的保护作用 ,与感染对照组的死亡率 (2 5 %)差异显著 (P<0 .0 1)。氟甲砜霉素及对照药物的增重效果显著高于感染对照组 (P<0 .0 1) ,中、高剂量组还能显著减少气囊损伤率 (P<0 .0 1) ,但氟甲砜霉素各用药组都不能减少抗体反应的阳性率。
The minimal inhibitory concentrations(MIC S) of florfenicol and enrofloxacin against Mycoplasma gallisepticum(MG) were determined by two-fold dilution,the MIC of florfenicol and enrofloxacin were respectively 1.25, 0.019 5 mg/L.The in vivo test showed that florfenicol given respectively at 300,400 and 500 mg/kg in feed additive for 5 successive days exhibited significantly protection in broiler chicken infected with MG but mortality of untreated group was 25%(P<0.01).The weight gain of groups treated with florfenicol and enrofloxacin were significantly higher than that of the positive control(P<0.01).The groups treated with a dosage of 400-500 mg/kg of florfenicol reduced significantly air sac lesions scores(P<0.01).However,all groups treated with florfenicol did not reduce the positive serum agglutination reaction,in contrast to the positive group.
出处
《中国兽医学报》
CAS
CSCD
北大核心
2002年第6期607-608,共2页
Chinese Journal of Veterinary Science
