摘要
目的 探讨高血压与胰岛素抵抗之间的关系。方法 2型糖尿病高血压组 110例 ,正常血压组112例。测定FPG、FINS、TC、MAU、血压、计算BMI,并评价胰岛素抵抗和 β细胞功能采用稳态模式评估法及改良胰岛素敏感性指数公式计算。结果 高血压组ISI显著低于正常血压组 ,HOMA βcell、HOMA IR显著高于正常血压组 (P <0 0 0 5 ) ,正常体重者也有相同的结果 (P <0 0 5 )。两组ISI与FPG、FINS、BMI均呈显著负相关 (P <0 0 5 ) ,高血压组ISI与TC、TG呈弱负相关 (P <0 5 )。结论 2型糖尿病伴高血压病人无论是否肥胖都存在胰岛素抵抗。肥胖病人胰岛素抵抗更为严重。
Objective To probe into the relationship between hypertension and insulin resistance.Methods Parameters such as FPG,FINS,TC,TG,MAU,Blood pressure and BMI were detected in 110 cases of type 2 diabetes with hypertension and 112 cases without hypertension.Homeostasis model assessment(HOMA) and the improves insulin sensitivity index(ISI) were appied to assess the status of insulin resistance and function of β cell.Results ISI with hypertension was lower than those with normotension significantly.FINS,HOMA-IR with hypertension was higher than those with normotension significantly(P<0.005).The simlilar results existed also inh normal body weight group(P<0.05).ISI was negatively correlated significantly with FPG,FINS,BMI in both groups(P<0.05).ISI was negtively correlated with TC,TG in hypertension group(P<0.5).Conclusion Whether obese or normal body weight,insulin resistance was existed in type 2 diabetes with hypertension.Insulin resistance in obses patients with type 2 diabetes is more serious.
出处
《中国基层医药》
CAS
2002年第10期905-906,共2页
Chinese Journal of Primary Medicine and Pharmacy
