摘要
本文报告了在北京市10个区县703.2万人口地区(含35所医院),使用标化乙肝血源疫苗和乙肝免疫球蛋白,对HBV不同感染情况孕妇的新生儿,采用不同免疫剂量、方案和不同免疫对策的研究结果。对HBsAg和HBeAg双阳性母亲的新生儿采用HBIG×2+20μg×3保护效果可达97.13％,为最佳免疫方案。对HBsAg单阳性母亲的新生儿仅接种较大剂量疫苗即可得到很好保护。对HBsAg阴性母亲的新生儿以按种20-10-10疫苗为宜。从而提出了北京地区应采取“在筛选基础上的全免策略”。
Studies on differet doses of HBV bloodderived vaccine and different vaeccination strategies were carried out in 10 districts or counties include up 7.03 millions of population in Beijing. The new born infants of mothers with positive reaction to both HBsAg and HBeAg, injected HBIG in smaller dose (20ug*3) twice, resulted in 97.13% of protective effect, The new born children of mothers with positive reaction only to HBsAg used vaccine (20-20-20 μg, 0-1-6 month) only revealed positive protectlve rate over 90%. The infants of mothers with negative reaction to HBsAg, antibody responce were observed through vaccination of different doses. The results suggested that vaccination of 30-10-10 μg and 2020-10μg were better than that of 10-10-10 μg. So it is clear that the best effects with least cost will be seen, if implementation of 3 vaccination strategies used in 3 different objects abovemetioned can be realized.
出处
《北京医学》
CAS
北大核心
1992年第2期65-68,共4页
Beijing Medical Journal
