摘要
本文利用分子杂交技术研究了在系膜增殖性肾小球炎症硬化过程中白细胞介素1(IL-1)及转化生长因子β(TGFβ)基因表达及系膜细胞IL-1的自分泌和旁分泌作用与细胞外基质合成的关系;研究了3种药物对于系膜细胞产生IL-1的影响。结果证实IL-1和TGFβ在肾小球炎症硬化过程中起着重要作用。
The accumulation of extracellular matrix is a prominent feature of progressive glomerulonephritisand glomerulosclerosis. The autocrine and paracrine of cytokines play a central role in the pathogenesisof glomerulonephritis and glomerulosclerosis.To evaluate the role of IL-1 on glomerulosclerosis, 1. we observed IL-1 and TGFβ mRNA ge-ne expression and cellular matrix accumulation during the development of glomerulosclerosis, 2. alsoeffect of rIL-1β on stimulating cultured MSc expressing IL-1 and TGFβ mRNA gene and producingcellular matrix were studied, 3. The influence of Dexamethasone (Dex.), Calcitonin generelated peptide(CGRP). Tamm-Horsfall glycoprotein (THP) on the suppression of IL-1 production and its increasingeffects on MSc proliferation was investigated.The exploration of both experimental and cellular studies indicates the IL-1 plays an impor-tant role in the development of glomerulosclerosis. These drugs antagonized IL-1 in MSc level whichmay stop the pathogenesis circle of MSc and IL-1.
出处
《北京医科大学学报》
CSCD
1992年第4期292-296,共5页
Journal of Peking University(Health Sciences)
关键词
白细胞介素
转化生长因子
系膜细胞
Interleukin 1
Transforming Growth Factor B
Mesangial Cell
