摘要
目的 了解老年骨折患者的骨转换状态及骨折对骨转换生化指标测定的影响。方法 选择 1 36例患者 ,包括女性 78例 ,按绝经与否和绝经后年限分为 4组。男性 58例 ,按年龄分为 3组。测定血清Ⅰ型胶原羧基端原肽 (CICP)及尿脱氧吡啶啉交联 (D Pyr)。结果 70岁以上男性骨折患者D Pyr,显著高于 50岁以下组 (P <0 0 5)。其CICP显著低于另两组 (P <0 0 1 )。女性骨折患者中绝经后 2 5年以上组的D Pyr,显著高于绝经前组 (P <0 0 5) ,其CICP显著高于绝经后 1 5～ 2 4年组(P <0 0 5)。D Pyr在骨折与非骨折成年男性患者间差异无显著性 (P >0 0 5) ,骨折组CICP显著低于非骨折组 (P <0 0 5)。结论 绝经 2 5年以上的女性骨折患者的骨转换为高转换型。 70岁以上男性骨折患者在成骨能力降低的基础上 ,骨吸收增加。骨折对D Pyr无显著影响 。
Objective\ To analyze the abnormality of bone turnover in elderly patients with fracture,and to explore the effect of fracture on the biochemical markers of bone turnover. Methods\ We measured serum collagen type Ⅰ C\|terminal propeptide(CICP) as a marker of bone formation and urine deoxypyridinoline crosslinks(D\|Pyr) as a marker of bone resorption in 136 patients,including 78 females and 58 males. Results\ D\|Pyr of the women with fractures who were postmenopausal over 25 years was significantly higher than that in the premenopausal controls ( P >0 05).CICP of the same group was significantly higher than that in the females who were postmenopausal between 15\|24 years ( P <0 05).D\|Pyr of the males older than 70 years was significantly higher than that in the adult controls ( P >0 05),while CICP was significantly lower than that in the other groups( P <0\^01).D\|Pyr of the adult males with fractures was not significantly different from that of the controls without fracture( P >0 05),while CICP was significantly lower than that in the controls( P <0 05). Conclusion\ High type of bone turnover appeared in elderly women who were postmenopausal over 25 years.Relatively increased bone resorption on the basis of decreased bone formation was found in elderly males over 70 years with fracture.Fracture did not significantly affect the D\|Pyr,while CICP was affected significantly.\;
出处
《中国骨质疏松杂志》
CAS
CSCD
2002年第4期324-325,295,共3页
Chinese Journal of Osteoporosis
关键词
骨折
骨转换
血清Ⅰ型胶原羧基端原肽
脱氧吡啶啉交联
老年人
Fracture
\ Bone turnover
\ Collagen type Ⅰ C\|terminal propeptide
\ Deoxypyridinoline crosslinks
