摘要
目的 探讨 5 羟色胺 2C(5 HT2C)受体基因启动区 - 759C/T和 - 697G/C单碱基置换多态性与精神分裂症伴迟发性运动障碍 (TD)的相关性。方法 先用异常不自主运动量表 (AIMS)评定精神分裂症男性患者有无TD及其严重程度 ,再对 42例符合TD(AIMS总分≥ 3分 )者和与TD组严格相匹配的 50例非TD者 ,采用简明精神病评定量表 (BPRS)评定精神症状 ,并应用聚合酶链反应 限制性片段长度多态性方法分析 5 HT2C受体基因的分布频率。结果 (1 )TD组的 - 697C(突变型 )半合子型频率 (38% )高于非TD组 (1 8% ;χ2 =4 7,P =0 0 3 ,OR =2 8)。TD组 - 759T(突变型 )半合子型频率和 - 759T/ - 697C突变型单倍体频率虽高于非TD组 ,但差异均无显著性 (χ2 值分别为 2 9和 4 9,P =0 0 9)。 (2 )TD组的AIMS和BPRS评分分别为 (6 5± 1 8)分和 (51 2± 7 8)分 ,非TD组分别为 0分和(50 0± 7 3)分 ,差异无显著性 (P >0 0 5)。结论 5 HT2C受体基因启动控制区的 -
Objective The present study was to investigate whether a polymorphism in the promoter region of the serotonin 2C (5 HT 2C ) receptor gene was associated with tardive dyskinesia (TD) in schizophrenic patients Methods Forty two male schizophrenic patients with TD and 50 without TD were entered the study The diagnosis of TD was made according to the Abnormal Involuntary Movement Scale (AIMS) score, with the AIMS score≥3 as having TD Psychiatric symptoms were rated using the Brief Psychiatric Rating Scale The 5 HT 2C receptor gene polymorphism was analyzed with the polymerase chain reaction restriction fragment length polymorphism Results A significant excess of -697C (mutant) (χ 2=4 7, P =0 03, OR =2 8) and a trend excess of -759T (χ 2=2 9, P =0 09) was in patients with TD compared to those without However, neither of the alleles -697C and -759T nor any clinical demographic characteristics were associated with the AIMS total scores in patients with TD There were no significant differences in clinical demographic characteristics and scores of clinical assessment between two allelic types of -759, or -697, in all schizophrenic patients or only patients with TD ( P >0 05) Conclusion The -697 mutant in the promoter regulation region of the 5 HT 2C receptor gene may be a risk factor for the susceptibility of TD in schizophrenic patients
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2002年第4期198-201,共4页
Chinese Journal of Psychiatry
基金
国家自然科学基金资助项目 ( 30 170 34 4)
