Synthesis of (1H)-3,4-Dihydropyrrolo[2,1-c][1,4]oxazin-1-one Derivatives 被引量：3

Synthesis of (1H)-3,4-Dihydropyrrolo[2,1-c][1,4]oxazin-1-one Derivatives

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摘要 In search of new anti-inflammatory and analgesic agents, (1H)-3,4-dihydro- pyrrolo [2,1-c][1,4]oxazin-1-one (3) and its acyl derivatives were designed and prepared. Compound 3 was prepared by treatment of methyl 1-(2-bromoethyl) pyrrole-2-carboxylate with silver oxide and its derivatives were obtained by Friedel-Craftes reaction. Nine of 6-acyl derivatives of compound 3 were prepared. In search of new anti-inflammatory and analgesic agents, (1H)-3,4-dihydro- pyrrolo [2,1-c][1,4]oxazin-1-one (3) and its acyl derivatives were designed and prepared. Compound 3 was prepared by treatment of methyl 1-(2-bromoethyl) pyrrole-2-carboxylate with silver oxide and its derivatives were obtained by Friedel-Craftes reaction. Nine of 6-acyl derivatives of compound 3 were prepared.

作者 De Cai FU Hong YU Shou Fang ZHANG

机构地区 Shenyang Pharmaceutical University

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第11期1051-1054,共4页 中国化学快报(英文版)

关键词 (1H)-3 4-Dihydropyrrolo[2 1-c][1 4]oxazin-1-one synthesis. (1H)-3,4-Dihydropyrrolo[2,1-c][1,4]oxazin-1-one synthesis.

分类号 O623 [理学—有机化学]

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Chinese Chemical Letters

2002年第11期

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Synthesis of (1H)-3,4-Dihydropyrrolo[2,1-c][1,4]oxazin-1-one Derivatives 被引量：3

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