摘要
目的 研究奥美拉唑对阻塞性黄疸肝细胞再生抑制的保护作用。方法 36只大鼠随机均分 3组 :外引流组、治疗组和对照组。观察反映肝细胞再生能力的增殖细胞核抗原 (proliferatingcellnuclearanti gen ,PCNA)肝细胞DNA含量和MI变化 ,全自动生化仪测定血清丙氨酸氨基转氨酶 (ALT)和胆红素 (TBil)。结果 B组大鼠残肝细胞PCNA标记指标、MI和细胞核DNA含量与A组和C组相比均有显著性增加 (P <0 0 1)。
Objective To study the effect of Omperazole on liver regeneration in cholestatic rats.Methods Rats were jaurdiced by ligating the drain tubes from common bile duct for 5 days,and jaundiced was released by external drainag.After another 5 days,70% hepatectomy was carried out.Omeprazole was injected intramusclarity once a day for three days follow 70% hepatectomy.The regeneration capacity of remained liver was setimated through PCNA labelling index,mitotic index and DNA content in the cell's muclei.Plasma glutamic pyruvic transaminase enzyme(ALT) and TBil were also measured.The histopathologic hepatic alteration were observed.Results The regeneration capacity of remained liver in the Omeprazole group remained significantly higher than that in the control group(P<0.05).Conclusion The Omeprazole may protect the regeneration capacity of remained liver inducd by external drainage.
出处
《中国基层医药》
CAS
2002年第11期997-998,共2页
Chinese Journal of Primary Medicine and Pharmacy
