摘要
目的 研究反复呼吸道感染患儿大剂量使用丙种球蛋白治疗前后免疫功能的变化。方法 利用T细胞亚群SAP法检测反复呼吸道感染患儿大剂量使用丙种球蛋白前及用药后 7d、30d后的CD3 、CD4、CD8细胞 ,用免疫比浊法检测IgA、IgM、IgG、C3 ,以正常婴幼儿 2 8例作为正常对照组 ,观察反复呼吸道感染患儿免疫功能的变化。结果 反复呼吸道感染患儿CD3 、CD4、CD4/CD8、IgA、IgG、IgM均低于正常对照组 ,患儿用丙种球蛋白 1周后 ,CD3 、CD4、CD8、CD4/CD8、C3 、IgA与用药前差别不大 ,P >0 0 5。患儿用丙种球蛋白后 1个月 ,CD4、CD4/CD8较用药前下降 ,P <0 0 5 ,IgA、IgG、IgM低于用药前 ,P <0 0 5。 结论 大剂量使用丙种球蛋白不能用来预防反复呼吸道感染 。
Objective To study the changes of immunologic function in children with recurrent respiratory tract infection before and after treatment with intravenous gamma globulin.Methods The CD 3,CD 4,CD 8 cells of the children with recurrent respiratory tract infection before and after(7d,30d) treatment with intravenous gamma globulin were detected by means of T cell subgroup SAP method.The IgA,IgM,IgG,C 3 were detected by means of immunization turbidimetry.In order to observe the changes of immunologic function in children with recurrent respiratory tract infection,28 normal infants and young children were selected as control group.Results The levels of CD 3,CD 4,CD 4/CD 8,IgA,IgG,IgM of the children with recurrent respiratory tract infection were lower than that in control group.The CD 3,CD 4,CD 8,CD 4/CD 8,C 3,IgA showed little variation in childhood patients who treated with intravenous gamma globulin for 1 week(P>0.05).CD 4,CD 4/CD 8 of the childhood patients decreased after medication for 1 month(P<0.05).IgA,IgG,IgM were lower than that before medication(P<0.05).Conclusion Intravenous gamma globulin could not be used to against recurrent respiratory tract infection,moreover,it would affect immunologic function of organism.
出处
《中国基层医药》
CAS
2002年第11期991-992,共2页
Chinese Journal of Primary Medicine and Pharmacy
