摘要
Ｍｅｔａｂｏｌｉｃｐｅｃｕｌｉａｒｉｔｙ ｏｆ^（１３４）ＣｓａｎｄｉｔｓｒａｄｉｏｉｍｍｕｎｏｔｏｘｉｃｏｌｏｇｉｃａｌｅｆｆｅｃｔｏｎｃｅｎｔｒａｌａｎｄｐｅｒｉｐｈｅｒａｌｉｍｍｕｎｅｃｅｌｌｓＺｈｕＳｈｏｕ－Ｐｅｎｇ（朱寿彭）ａｎｄＸｉａＦｅ?..
A fitted equation with least square method to describe the retention of 134Csin whole body is obtained by a whole body counter. That is R(t) = 18.04exp(-9.3175t) +45.13exp(-0.0423t), where R(t) is in %, and t in d. The equation consists of two half-life components, the fast component is T1/2 = 0.07d, and the slow is T1/2 = 16.14d. Study on the localization of 134Cs at cellular level was carried out by freezing The results indicate that 134Cs was chiefly in ionizing form accumulated in red as well as white blood cells. In bone marrow cells 134Cs predominantly deposited in young cells and less in mature cells. Distribution of 134Cs in soft tissues such as muscle, liver and cerebrum was observed. It should be hoted that 134Cs penetrated quickly into the tissue cells. The observation of investigating radioimmunotoxicological effect induced by 134Cs shows t hat the inhibition of thymocytes is higher than bone marrow cells, the spleen T lymphocytes are more sensitive to 134Cs than B lymphocytes and lymphocytes of peripheral immune cells are more sensitive to radiation than central immune cells.
关键词
放射医学核素^134Cs
新陈代谢
免疫细胞
Signal nuclide 134Cs, Metabolic peculiaxity, Autoradiography, Radioimmunotoxicological effect, Central immune cells, Peripheral immune cells
