摘要
本文应用显微分光光度计测定32例大肠活检粘膜细胞核DNA含量。结果表明:11例大肠腺癌细胞核DNA含量高于正常肠粘膜上皮细胞核DNA含量;18例大肠息肉细胞核DNA含量介于正常肠粘膜和大胸腺癌之间(P<0.01)。检测细胞核DNA含量,可用于判定大肠癌及癌前病变,并可作为判定早期大肠癌的定量指标。
In this experiment, nuclear DNA content in bioptic colonic mucous membrane cells was microspectrophotometric ally determined in 32 patients suffering from malignant and benign col-orectal diseases. The results showed that the nuclear DNA content in 11 patients with adenomas of the large intestine was higher than that in the normal colonic mucous membrane cells and that the nuclear DNA content in 18 patients suffering from colonic polyps was intermediate between that of the normal colonic mucous membrane cells and the colonic adenoma (P<0. 01). These results suggest that mi-crospectrophotometric measurement of nuclear DNA content may serve as an objective quantitative method for diagnosis of malignant and precancerous colorectal diseases. We have found that the nuclear DNA content may serve as the quantitative index for early colorectal carcinoma.
出处
《白求恩医科大学学报》
CSCD
1992年第3期254-256,共3页
Journal of Norman Bethune University of Medical Science
关键词
大肠癌
癌前病变
DNA含量
Colorectal cancer Precancer lesion DNA content Microdensitometer
