Animal models of genetic causes of male infertility
Animal models of genetic causes of male infertility
摘要
Introduction In the past 10 years, more than 100 different genetically engineered mice have been developed with an abnormality in spermatogenesis. More than half of these male infertility animal models have been reported in the past three years alone. Spermatogenic defects in these models vary considerably, ranging from the inappropriate migration of primordial germ cells to the inability of mature spermatozoa to bind the zona pellucida. Many of
参考文献10
-
1Venables,JP,Cooke,HJ.Lessons from knockout and transgenic mice for infertility in men[].Journal of Endocrinological Investigation.2000
-
2Bouchard MJ,Dong Y,McDermott BM Jr,Lam DH,Brown KR,Shelanski M,et al.Defects in nuclear and cytoskeletal morphology and mitochondrial localization in spermatozoa of mice lacking nectin-2, a component of cell-cell adherens junctions[].Molecular and Cellular Biology.2000
-
3Yuan L,Liu JG,Hoja MR,Wilbertz J,Nordqvist K,Hoog C.Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3[].Science.2002
-
4Yeung CH,Wagenfeld a,Nieschlag E,Cooper TG.The cause of infertility in c-ros tyrosine kinase receptor knockout mice[].Biology of Reproduction.2000
-
5Tourtellotte WG,Nagarajan R,Auyeung A,Mueller C,Milbrandt J.Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice[].Development.1999
-
6Yeung CH,Sonnenberg-Riethmacher E,Cooper TG.Infertile spermatozoa of c-ros tyrosine kinase receptor knockout mice show flagellar angulation and maturational defects in cell volume regulatory mechanisms[].Biology of Reproduction.1999
-
7Shamsadin R,Adham IM,Nayernia K,Heinlein UA,Oberwinkler H,Engel W.Male mice deficient for germ-cell cyritestin are infertile[].Biology of Reproduction.1999
-
8Baker SM,Bronner CE,Zhang L,Plug AW,Robatzek M,Warren G,et al.Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis[].Cell.1995
-
9Thepot D,Weitzman JB,Barra J,Segretain D,Stinnakre MG,Babinet C,et al.Targeted disruption of the murinejun D gene results in multiple defects in male reproductive function[].Development.2000
-
10Komada M,McLean DJ,Griswold MD,Russell LD,Soriano P.E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis[].Genes and Development.2000
-
1li Hongjun.UROGENITAL SURGERY Spermatic cord[J].China Medical Abstracts,2008,17(2):142-142.
-
2FU Qing -lin ZHANG Xin - zhong HAN Pei - li SHI Rui -feng.The evaluation of aprotinin contained preservation solution with a new animal model[J].医学信息（手术学分册）,2008,21(11):963-966.
-
3冯勇,郑东,杨述华,李进.Construction of Eukaryotic Expression Plasmid of bFGF Gene in Rats and Its Expression in Tenocytes[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2007,27(1):27-30.
-
4李其一,邱贵兴,王以朋,吴志宏.脊柱侧凸动物模型[J].协和医学杂志,2011,2(1):85-88.
-
5刘刚,辛钟成.男性不育症相关基因研究进展[J].中国男科学杂志,2006,20(9):43-46. 被引量：2
-
6B.N.Truong,E.K.Moses,J.E.Armes,D.J.Venter,H.W.G.Baker.Searching for candidate genes for male infertility[J].Asian Journal of Andrology,2003,5(2):137-147. 被引量：15
-
7宋春生,赵家有.《EAU男性不育症指南(2012年版)》解读[J].中国性科学,2012,21(10):13-16. 被引量：52
-
8Hui-BinZhu JunLu Li-NanCheng Yin-KunLiu.Studies on microdeletion of genes relevant to spermatoge nesis in infertile men[J].Asian Journal of Andrology,2004,6(1):66-66.
-
9WeiChen,Song-ShanJiang,Shi-LingChen,Fu-QiXing.Single Nucieotide Polymorphisms in a male infertility-related cene CatSper[J].Asian Journal of Andrology,2004,6(3):258-258.
-
10Xue-Jun SHANG,Yu-Feng HUANG,Cheng-Liang XIONG,Jian-Ping XU,Lai YIN,Chang-Chun WAN Center of Reproductive Medicine, Tongji Medical University, Wuhan 430030, China Department of Reproduction and Genetics, Medical Laboratory Science Center, Jinling Hospital, Nanjing 210002, China.Ureaplasma urealyticum infection and apoptosis of spermatogenic cells[J].Asian Journal of Andrology,1999,1(3):127-129. 被引量：16
