摘要
我院1985年1422例首程放疗的鼻咽癌患者五年内复发214例。原发灶与颈淋巴结五年复发率分别为11.18和7.17％,头三年内复发占85.05％。本文资料显示原发灶复发与首程放疗靶区遗漏有密切关系,颈淋巴结复发与首程放疗前的大小及活动度有密切关系。提示减少复发的关键在于首程放疗,要做到准确确定靶区范围和合理设计照射野。再程放疗由于仍是简单重复首程放疗方法,故疗效不佳,与未再程放疗比较,仅显示SR_1有差别(P<0.05),放疗组中,颈淋巴结复发的SR_3较原发灶、原发灶加颈淋巴结同时复发组有明显差别(P<0、01)、再程放疗的后遗症发生相当高,提示需个别化地选用最佳方案行再程放疗及需要寻找优于单纯放疗的综合治疗方案,才能提高再程放疗的效果及改善生存质量。
Among 1422 cases of NPC after initial radiotherapy in 1985, two hundreds and fourteen cases were recurrent within five years, The recurrent rates of primary tumor and neck lymphnodes were 11.18% and 7.71% within 5-years, respectively. 182 cases (85.05%) recurred in the first three years. The study showed that the recurrence of primary tumor was closely related to target field ommission in the initial radio therapy, and the recurrence of neck lymphnode was closely related to the size and mobility of the meta-static lymphnodes.The one year survival rate in the group after second course radiotherapy s howed a better result as compared to that of the group without re-radiation (P<0.05 ). It was especially true in the cases only with recurrent cervical lymphnodes but with no primary lesion recurrent (P<0.01). However the adverse radiation sequelae were rather common in the patients after re-radiation. So that the author suggested that the second course of radiotherapy should be adopted individually and carefully. It is urgent to seek the combined treatment method so as to elevate the therapeutic result and improve the life quality of NPC patients.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1992年第5期375-379,共5页
Chinese Journal of Cancer
关键词
复发
鼻咽肿瘤
放射疗法
Nasopharyngeal carcinoma Radiotherapy Recurrence Re-irradeation
