摘要
目的 本课题旨在探讨危重病患者心肌损伤的可能机制 ,并对综合性重症监护病房患者的心肌损伤进行研究。方法 利用心肌肌钙蛋白 T和肿瘤坏死因子两指标测定 ,对综合性重症监护病房内 1 5例 APACHE ≥ 1 6危重病患者和 2 0例健康献血员进行对比研究。结果 1危重病患者心肌肌钙蛋白 T浓度明显高于健康献血员 ,其中死亡组又明显高于存活组 (P<0 .0 1 )。2危重病患者的肿瘤坏死因子亦显著高于健康献血员 ,且其中死亡组也显著高于存活组 (P<0 .0 1 )。 3在危重病患者发病后第 4、 2 4小时心肌肌钙蛋白 T与肿瘤坏死因子浓度间存在正相关 (r4 =0 .72 1 5P<0 .0 1 ,r2 4 =0 .770 5 P<0 .0 1 )。结论 1在危重病患者中存在着急性心肌损伤 ,且与心肌损伤患者的预后相关。
Objective The myocardial injury in the critical ill patients in general ICU(Intensive Care Unit)Was prospectively studiedto explore the mechanism of myocardial injury in the critical ill patients.Methods The serum cardiac troponin T and tumor necrosis factor levels of 15 critical ill patients(APACHE Ⅱ≥16) and of 20 normal donators were compared with each other.Results ①The cardiac troponin T levels in the critical ill patients were significantly higher than those of the donators,and the levels of the dead group were significantly higher than those of the survivals in the critical ill patients;②The tumor necrosis factor levels of the critical ill patients were significantly higher than those of the donators,and the levels of the dead group in the critical ill patients were significantly higher than those of the survivals;③There were significant positive relations between cardiac troponin T and tumor necrosis factor at 4,24 hours post onset of the diseases in the critical ill patients(r=0 7215 P<0 01,r=0 7705 P<0 01). Conclusions ①The myocardial injury is present in critical ill patients and could judge the prognoses of the critical ill patients.②The tumor necrosis factor may play an important role in the pathophysiological processes of myocardial injury in the critical ill patients.
出处
《心脑血管病防治》
2001年第1期13-15,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
