摘要
目的探讨超声检测糖尿病患者颈动脉弹性功能指标与血清MMP9的关系。方法选取2016年5月至2018年3月间我院收治的糖尿病患者142例分为:内膜正常组62例,内膜改变组(颈动脉内膜增厚或斑块形成)80例;另取同年龄段在本院行健康体检的颈动脉正常的健康人60例为健康对照组。采用血管回声跟踪技术检测颈动脉的顺应性、膨大指数、僵硬指数、脉搏传导速度、压力弹性应变系数,Elisa法检测血清MMP9水平,分析二者的相关性。结果内膜正常组和内膜改变组MMP9水平高于健康对照组,内膜改变组MMP9水平高于内膜正常组,差异有统计学意义(P<0.05)。内膜正常组和内膜改变组的顺应性低于健康对照组,膨大指数、僵硬指数、脉搏传导速度、压力弹性应变系数高于健康对照组,差异有统计学意义(P<0.05);内膜改变组的顺应性低于内膜正常组,僵硬指数、脉搏传导速度、压力弹性应变系数明显高于健康对照组,差异有统计学意义(P<0.05);内膜改变组与内膜正常组的膨大指数之间差异无统计学意义(P>0.05)。相关性分析显示,内膜正常组糖尿病患者血清MMP9水平与脉搏传导速度、压力弹性应变系数呈正相关,与顺应性呈负相关;内膜改变组糖尿病患者血清MMP9水平与僵硬指数、压力弹性应变系数呈正相关,与顺应性呈负相关。结论糖尿病患者颈动脉内膜未出现明显改变时,颈动脉血管弹性功能和血清MMP9水平较颈动脉正常的健康人已出现改变,且存在相关性,可作为糖尿病患者早期动脉粥样硬化的敏感指标。
Objective To investigate the relationship between carotid elastic function and serum MMP-9 in diabetic patients by ultrasound.Methods From May 2016 to March 2018,142 patients with diabetes mellitus were enrolled into our study,and were divided into two groups:62 patients with normal intima called normal endometrium group,80 patients with intima change(carotid intima thickening or plaque formation)called altered endometrium group,and 60 healthy people with normal carotid artery were selected as healthy subjects.The compliance,swelling index,stiffness index,pulse conduction velocity and pressure elastic strain coefficient of carotid artery were measured by echo tracking technique.The level of serum MMP9 was measured by Elisa method,and the correlation between them was analyzed.Results The levels of MMP-9 in normal endometrium group and altered endometrium group were significantly higher than those in healthy control group.The levels of MMP-9 in altered endometrium group were significantly higher than those in normal endometrium group(P<0.05).The carotid artery compliance of normal endometrium group and altered endometrium group was significantly lower than that of healthy control group,and the swelling index,stiffness index,pulse conduction velocity,pressure elastic strain coefficient were significantly higher than that of healthy control group(P<0.05).The conduction velocity and pressure elastic strain coefficient were significantly higher than those of the healthy control group(P<0.05),and there was no significant difference between the enlargement index of the endometrial change group and the normal group(P>0.05).Correlation analysis showed that MMP9 levels in diabetic patients with normal intima were positively correlated with pulse conduction velocity and pressure elastic strain coefficient,and negatively correlated with compliance;MMP9 levels in diabetic patients with endometrial change were positively correlated with stiffness index and pressure elastic strain coefficient,and negatively correlated with compliance.Conclusion The carotid intima of diabetic patients did not change significantly,the carotid artery elasticity function and serum MMP9 level had changed compared with those of healthy people with normal carotid artery,and there was a correlation between them.It could be used as a sensitive index of early atherosclerosis in diabetic patients.
作者
张静
Zhang Jing(Department of ultrasound, staff hospital of Luoyang North Enterprise Group Co. ,Ltd. ,Luoyang ,Henan 471000)
出处
《辽宁医学杂志》
2019年第5期9-12,共4页
Medical Journal of Liaoning
