摘要
目的研究基于金电极、玻碳电极、碳糊电极、丝网印刷电极和ITO玻璃电极(5种工作电极)可检测核酸的5种检测系统的经济效果。方法以完成单次检测的成本作为经济学分析的成本,以约登指数代表效果进行成本-效果分析(CEA),同时应用成本-效用分析(CUA)、增量成本-效果比(ICER)对相应检测系统进行经济学分析。结果基于金电极、玻碳电极、碳糊电极、丝网印刷电极和ITO玻璃电极的5种检测系统的成本分别是3.70元/支、4.20元/支、5.25元/支、33.98元/支和5.01元/支,5种检测方法的约登指数均为1。5种检测系统的C/E分别是3.70、4.20、5.25、33.98和5.01;C/U分别是6.61、6.89、9.91、62.93和9.45。应用金电极的检测系统的C’/E和C’/U均最小(2.96、5.29)。使用玻碳电极的系统相对使用金电极的系统而言,△C>0、△E0>0;而使用碳糊电极、丝网印刷电极、ITO玻璃电极的系统时,其△C>0、△E0<0。结论从CEA和CUA角度看,使用金电极的检测核酸的电化学生物传感器系统具有较好的经济效果。敏感性分析证明了CEA和CUA结果的可靠性。经ICER可知,临床上使用金电极的系统或玻碳电极的系统均可供考虑,选择何种系统由使用者的意愿决定。
Objectives This study aimed to study the economic effect of five kinds of detection systems for nucleic acid, which were based on five kinds of working electrodes: gold electrode, glassy carbon electrode, carbon paste electrode, screen printing electrode, and indium-tin-oxide(ITO) glass electrode. Methods The cost of completing a single test was taken as the cost of economic analysis. The Youden index was used to represent the effect of costeffectiveness analysis(CEA). Meanwhile, the cost-utility analysis(CUA) and incremental cost-effectiveness ratio(ICER)were used for the economic analysis of the corresponding system. Results The cost of five detection systems based on gold electrode, glass carbon electrode, carbon paste electrode, screen printing electrode, and ITO glass electrode was 3.70 yuan/unit, 4.20 yuan/unit, 5.25 yuan/unit, 33.98 yuan/unit and 5.01 yuan/unit, respectively. The Youden indexes of all five systems were 1. The cost effectiveness(C/E) were 3.70, 4.20, 5.25, 33.98, and 5.01, respectively. The cost utility(C/U) were6.61, 6.89, 9.91, 62.93, and 9.45, respectively. The C’/E and C’/U of the gold electrode detection system were the minimum(2.96 and 5.29). Compared with the system applying the gold electrode, the system using the glassy carbon electrode had ΔC >0 and△E0 >0;When carbon paste electrode, screen printing electrode, and ITO glass electrode system were used,△C was >0 and△E0 was <0. Conclusions From the perspective of CEA and CUA, the system using the gold electrode has the best economic effect. The sensitivity analysis proved the reliability of CEA and CUA results. According to the ICER, gold electrode or glassy carbon electrode can be used in clinical practice with the choice depending on the user.
作者
王梦鹤
明德松
WANG Menghe;MING Desong(Department of Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2019年第10期1244-1249,共6页
Chinese Journal of Evidence-based Medicine
基金
福建省自然科学基金项目（编号：2015J01514）
泉州高层次人才创新创业项目（编号：2017Z36）
关键词
成本-效果分析
成本-效用分析
增量成本-效果比
金电极
玻碳电极
碳糊电极
丝网印刷电极
ITO玻璃电极
Cost-effectiveness analysis
Cost-utility analysis
Incremental cost-effectiveness ration
Gold electrode
Glassy carbon electrode
Carbon paste electrode
Screen-printed electrode
ITO glass electrode
